Masmanidis, Sotiris


Associate Professor, Neurobiology

Member, Brain Research Institute

California NanoSystems Institute

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroscience GPB Home Area

Contact Information

Lab Number: 310-794-5625


Sotiris Masmanidis received an undergraduate degree in Physics from University College London, and a PhD in Applied Physics from the California Institute of Technology.  He was then awarded a Broad Fellowship in Brain Circuitry, and transitioned to neuroscience.  In 2012 he joined the faculty in the Department of Neurobiology at UCLA, and was promoted to Associate Professor in 2019.

Research Interests

Neural circuits of reward learning and motor control, addiction, movement disorders

Learning and movement are fundamental functions of the brain, yet many aspects of how these processes are orchestrated by various circuits remain elusive. Our group is addressing several open questions about the neurobiological basis of learning and movement in health and disease.  Specific questions include:

1. What are the dynamics of neural microcircuits during reward-conditioned behavior?

2. What role do specific microcircuits play in learning and movement?

3. How do brain disorders perturb neural dynamics and information processing?



A selected list of publications:

Lee Kwang, Claar Leslie D, Hachisuka Ayaka, Bakhurin Konstantin I, Nguyen Jacquelyn, Trott Jeremy M, Gill Jay L, Masmanidis Sotiris C   Temporally restricted dopaminergic control of reward-conditioned movements Nature neuroscience, 2020; .
Lee Kwang, Bakhurin Konstantin I, Claar Leslie D, Holley Sandra M, Chong Natalie C, Cepeda Carlos, Levine Michael S, Masmanidis Sotiris C   Gain Modulation by Corticostriatal and Thalamostriatal Input Signals during Reward-Conditioned Behavior Cell reports, 2019; 29(8): 2438-2449.e4.
Yang Long, Lee Kwang, Villagracia Jomar, Masmanidis Sotiris C   Open source silicon microprobes for high throughput neural recording Journal of neural engineering, 2019; .
Bakhurin Konstantin I, Goudar Vishwa, Shobe Justin L, Claar Leslie D, Buonomano Dean V, Masmanidis Sotiris C   Differential Encoding of Time by Prefrontal and Striatal Network Dynamics The Journal of Neuroscience, 2017; 37(4): 854-870.
Lee Kwang, Holley Sandra M, Shobe Justin L, Chong Natalie C, Cepeda Carlos, Levine Michael S, Masmanidis Sotiris C   Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning Neuron, 2017; 93(6): 1451-1463.e4.
Shobe Justin L, Bakhurin Konstantin I, Claar Leslie D, Masmanidis Sotiris C   Selective modulation of orbitofrontal network activity during negative occasion setting The Journal of Neuroscience, 2017; .