Liau, Linda

Professor, Neurosurgery

Molecular & Medical Pharmacology

Member, Brain Research Institute

CTSI

Immunity, Microbes & Molecular Pathogenesis GPB Home Area

JCCC Signal Transduction and Therapeutics Program Area

Molecular Pharmacology GPB Home Area

Neuroscience GPB Home Area

Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)

Awards and Honors:

University of California, Los Angeles

UCLA School of Medicine

UCLA School of Medicine

Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J   An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity Cancer research, 2013; 73(9): 2850-2862.

Lasky Joseph L, Panosyan Eduard H, Plant Ashley, Davidson Tom, Yong William H, Prins Robert M, Liau Linda M, Moore Theodore B   Autologous Tumor Lysate-pulsed Dendritic Cell Immunotherapy for Pediatric Patients with Newly Diagnosed or Recurrent High-grade Gliomas Anticancer research, 2013; 33(5): 2047-56.

Lalezari Shadi, Chou Arthur P, Tran Anh, Solis Orestes E, Khanlou Negar, Chen Weidong, Li Sichen, Carrillo Jose A, Chowdhury Reshmi, Selfridge Julia, Sanchez Desiree E, Wilson Ryan W, Zurayk Mira, Lalezari Jonathan, Lou Jerry J, Ormiston Laurel, Ancheta Karen, Hanna Robert, Miller Paul, Piccioni David, Ellingson Benjamin M, Buchanan Colin, Mischel Paul S, Nghiemphu Phioanh L, Green Richard, Wang He-Jing, Pope Whitney B, Liau Linda M, Elashoff Robert M, Cloughesy Timothy F, Yong William H, Lai Albert   Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome Neuro-oncology, 2013; 15(3): 370-81.

Prins Robert M, Wang Xiaoyan, Soto Horacio, Young Emma, Lisiero Dominique N, Fong Brendan, Everson Richard, Yong William H, Lai Albert, Li Gang, Cloughesy Timothy F, Liau Linda M   Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients Journal of immunotherapy (Hagerstown, Md. : 1997), 2013; 36(2): 152-7.

Mareninov Sergey, De Jesus Jason, Sanchez Desiree E, Kay Andrew B, Wilson Ryan W, Babic Ivan, Chen Weidong, Telesca Donatello, Lou Jerry J, Mirsadraei Leili, Gardner Tracie P, Khanlou Negar, Vinters Harry V, Shafa Bob B, Lai Albert, Liau Linda M, Mischel Paul S, Cloughesy Timothy F, Yong William H   Lyophilized brain tumor specimens can be used for histologic, nucleic acid, and protein analyses after 1 year of room temperature storage Journal of neuro-oncology, 2013; .

Li Sichen, Chou Arthur P, Chen Weidong, Chen Ruihuan, Deng Yuzhong, Phillips Heidi S, Selfridge Julia, Zurayk Mira, Lou Jerry J, Everson Richard G, Wu Kuan-Chung, Faull Kym F, Cloughesy Timothy, Liau Linda M, Lai Albert   Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation Neuro-oncology, 2013; 15(1): 57-68.

Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Pope Whitney B   Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapy Neuro-oncology, 2013; 15(3): 382-90.

Morris Luc G T, Kaufman Andrew M, Gong Yongxing, Ramaswami Deepa, Walsh Logan A, Turcan Şevin, Eng Stephanie, Kannan Kasthuri, Zou Yilong, Peng Luke, Banuchi Victoria E, Paty Phillip, Zeng Zhaoshi, Vakiani Efsevia, Solit David, Singh Bhuvanesh, Ganly Ian, Liau Linda, Cloughesy Timothy C, Mischel Paul S, Mellinghoff Ingo K, Chan Timothy A   Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation Nature genetics, 2013; 45(3): 253-61.

Lazovic Jelena, Soto Horacio, Piccioni David, Lou Jerry R, Li Sichen, Mirsadraei Leili, Yong William, Prins Robert, Liau Linda M, Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Pope Whitney B   Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation Neuro-oncology, 2012; 14(12): 1465-72.

Vivanco Igor, Robins H Ian, Rohle Daniel, Campos Carl, Grommes Christian, Nghiemphu Phioanh Leia, Kubek Sara, Oldrini Barbara, Chheda Milan G, Yannuzzi Nicolas, Tao Hui, Zhu Shaojun, Iwanami Akio, Kuga Daisuke, Dang Julie, Pedraza Alicia, Brennan Cameron W, Heguy Adriana, Liau Linda M, Lieberman Frank, Yung W K Alfred, Gilbert Mark R, Reardon David A, Drappatz Jan, Wen Patrick Y, Lamborn Kathleen R, Chang Susan M, Prados Michael D, Fine Howard A, Horvath Steve, Wu Nian, Lassman Andrew B, DeAngelis Lisa M, Yong William H, Kuhn John G, Mischel Paul S, Mehta Minesh P, Cloughesy Timothy F, Mellinghoff Ingo K   Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors Cancer discovery, 2012; 2(5): 458-71.

Yang Jian, Nagasawa Daniel T, Spasic Marko, Amolis Misha, Choy Winward, Garcia Heather M, Prins Robert M, Liau Linda M, Yang Isaac   Endogenous vaults and bioengineered vault nanoparticles for treatment of glioblastomas: implications for future targeted therapies Neurosurgery clinics of North America, 2012; 23(3): 451-8.

Ellingson Benjamin M, Cloughesy Timothy F, Zaw Taryar, Lai Albert, Nghiemphu Phioanh L, Harris Robert, Lalezari Shadi, Wagle Naveed, Naeini Kourosh M, Carrillo Jose, Liau Linda M, Pope Whitney B   Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma Neuro-oncology, 2012; 14(3): 333-43.

Kim Won, Liau Linda M   IDH mutations in human glioma Neurosurgery clinics of North America, 2012; 23(3): 471-80.

Chou Arthur P, Chowdhury Reshmi, Li Sichen, Chen Weidong, Kim Andrew J, Piccioni David E, Selfridge Julia M, Mody Reema R, Chang Stephen, Lalezari Shadi, Lin Jeffrey, Sanchez Desiree E, Wilson Ryan W, Garrett Matthew C, Harry Bret, Mottahedeh Jack, Nghiemphu Phioanh L, Kornblum Harley I, Mischel Paul S, Prins Robert M, Yong William H, Cloughesy Timothy, Nelson Stanley F, Liau Linda M, Lai Albert   Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas Journal of the National Cancer Institute, 2012; 104(19): 1458-69.

Hickey Michelle J, Malone Colin C, Erickson Kate E, Gomez German G, Young Emma L, Liau Linda M, Prins Robert M, Kruse Carol A   Implementing preclinical study findings to protocol design: translational studies with alloreactive CTL for gliomas American journal of translational research, 2012; 4(1): 114-26.

Fong Brendan, Jin Richard, Wang Xiaoyan, Safaee Michael, Lisiero Dominique N, Yang Isaac, Li Gang, Liau Linda M, Prins Robert M   Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients PloS one, 2012; 7(4): e32614.

Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M   Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy Journal of neuro-oncology, 2012; 107(1): 197-205.

Northcott Paul A, Shih David J H, Peacock John, Garzia Livia, Morrissy A Sorana, Zichner Thomas, Stütz Adrian M, Korshunov Andrey, Reimand Jüri, Schumacher Steven E, Beroukhim Rameen, Ellison David W, Marshall Christian R, Lionel Anath C, Mack Stephen, Dubuc Adrian, Yao Yuan, Ramaswamy Vijay, Luu Betty, Rolider Adi, Cavalli Florence M G, Wang Xin, Remke Marc, Wu Xiaochong, Chiu Readman Y B, Chu Andy, Chuah Eric, Corbett Richard D, Hoad Gemma R, Jackman Shaun D, Li Yisu, Lo Allan, Mungall Karen L, Nip Ka Ming, Qian Jenny Q, Raymond Anthony G J, Thiessen Nina T, Varhol Richard J, Birol Inanc, Moore Richard A, Mungall Andrew J, Holt Robert, Kawauchi Daisuke, Roussel Martine F, Kool Marcel, Jones David T W, Witt Hendrick, Fernandez-L Africa, Kenney Anna M, Wechsler-Reya Robert J, Dirks Peter, Aviv Tzvi, Grajkowska Wieslawa A, Perek-Polnik Marta, Haberler Christine C, Delattre Olivier, Reynaud Stéphanie S, Doz François F, Pernet-Fattet Sarah S, Cho Byung-Kyu, Kim Seung-Ki, Wang Kyu-Chang, Scheurlen Wolfram, Eberhart Charles G, Fèvre-Montange Michelle, Jouvet Anne, Pollack Ian F, Fan Xing, Muraszko Karin M, Gillespie G Yancey, Di Rocco Concezio, Massimi Luca, Michiels Erna M C, Kloosterhof Nanne K, French Pim J, Kros Johan M, Olson James M, Ellenbogen Richard G, Zitterbart Karel, Kren Leos, Thompson Reid C, Cooper Michael K, Lach Boleslaw, McLendon Roger E, Bigner Darell D, Fontebasso Adam, Albrecht Steffen, Jabado Nada, Lindsey Janet C, Bailey Simon, Gupta Nalin, Weiss William A, Bognár László, Klekner Almos, Van Meter Timothy E, Kumabe Toshihiro, Tominaga Teiji, Elbabaa Samer K, Leonard Jeffrey R, Rubin Joshua B, Liau Linda M, Van Meir Erwin G, Fouladi Maryam, Nakamura Hideo, Cinalli Giuseppe, Garami Miklós, Hauser Peter, Saad Ali G, Iolascon Achille, Jung Shin, Carlotti Carlos G, Vibhakar Rajeev, Ra Young Shin, Robinson Shenandoah, Zollo Massimo, Faria Claudia C, Chan Jennifer A, Levy Michael L, Sorensen Poul H B, Meyerson Matthew, Pomeroy Scott L, Cho Yoon-Jae, Bader Gary D, Tabori Uri, Hawkins Cynthia E, Bouffet Eric, Scherer Stephen W, Rutka James T, Malkin David, Clifford Steven C, Jones Steven J M, Korbel Jan O, Pfister Stefan M, Marra Marco A, Taylor Michael D   Subgroup-specific structural variation across 1,000 medulloblastoma genomes Nature, 2012; 488(7409): 49-56.

Garrett Matthew C, Pouratian Nader, Liau Linda M   Use of language mapping to aid in resection of gliomas in eloquent brain regions Neurosurgery clinics of North America, 2012; 23(3): 497-506.

Liu Yue, Ye Fei, Yamada Kazunari, Tso Jonathan L, Zhang Yibei, Nguyen David H, Dong Qinghua, Soto Horacio, Choe Jinny, Dembo Anna, Wheeler Hayley, Eskin Ascia, Schmid Ingrid, Yong William H, Mischel Paul S, Cloughesy Timothy F, Kornblum Harley I, Nelson Stanley F, Liau Linda M, Tso Cho-Lea   Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells Molecular cancer research : MCR, 2011; 9(12): 1668-85.

Konkankit Veerauo V, Kim Won, Koya Richard C, Eskin Ascia, Dam Mai-Anh, Nelson Stanley, Ribas Antoni, Liau Linda M, Prins Robert M   Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway Journal of translational medicine, 2011; 9(12): 192.

Lisiero Dominique N, Soto Horacio, Liau Linda M, Prins Robert M   Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model Journal of immunology (Baltimore, Md. : 1950), 2011; 186(9): 5068-77.

Lai Albert, Kharbanda Samir, Pope Whitney B, Tran Anh, Solis Orestes E, Peale Franklin, Forrest William F, Pujara Kanan, Carrillo Jose A, Pandita Ajay, Ellingson Benjamin M, Bowers Chauncey W, Soriano Robert H, Schmidt Nils O, Mohan Sankar, Yong William H, Seshagiri Somasekar, Modrusan Zora, Jiang Zhaoshi, Aldape Kenneth D, Mischel Paul S, Liau Linda M, Escovedo Cameron J, Chen Weidong, Nghiemphu Phioanh Leia, James C David, Prados Michael D, Westphal Manfred, Lamszus Katrin, Cloughesy Timothy, Phillips Heidi S   Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011; 29(34): 4482-90.

Prins Robert M, Soto Horacio, Konkankit Vera, Odesa Sylvia K, Eskin Ascia, Yong William H, Nelson Stanley F, Liau Linda M   Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy Clinical cancer research : an official journal of the American Association for Cancer Research, 2011; 17(6): 1603-15.

Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Pope Whitney B   High order diffusion tensor imaging in human glioblastoma Academic radiology, 2011; 18(8): 947-54.

Sun Shan, Wang Qiuwei, Giang An, Cheng Cong, Soo Chia, Wang Cun-Yu, Liau Linda M, Chiu Robert   Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB Journal of neuro-oncology, 2011; 101(1): 1-14.

Lai Albert, Tran Anh, Nghiemphu Phioanh L, Pope Whitney B, Solis Orestes E, Selch Michael, Filka Emese, Yong William H, Mischel Paul S, Liau Linda M, Phuphanich Surasak, Black Keith, Peak Scott, Green Richard M, Spier Cynthia E, Kolevska Tatjana, Polikoff Jonathan, Fehrenbacher Louis, Elashoff Robert, Cloughesy Timothy   Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011; 29(2): 142-8.

Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong   A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens Cancer research, 2010; 70(15): 6128-38.

Yang Isaac, Liau Linda M   American Association for Cancer Research Genetics and Biology of Brain Cancers 2009, December 13-15, 2009, San Diego, CA Journal of neuro-oncology, 2010; 99(2): 297-306.

Dang Lenny, White David W, Gross Stefan, Bennett Bryson D, Bittinger Mark A, Driggers Edward M, Fantin Valeria R, Jang Hyun Gyung, Jin Shengfang, Keenan Marie C, Marks Kevin M, Prins Robert M, Ward Patrick S, Yen Katharine E, Liau Linda M, Rabinowitz Joshua D, Cantley Lewis C, Thompson Craig B, Vander Heiden Matthew G, Su Shinsan M   Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature, 2010; 465(7300): 966.

Hickey Michelle J, Malone Colin C, Erickson Kate L, Jadus Martin R, Prins Robert M, Liau Linda M, Kruse Carol A   Cellular and vaccine therapeutic approaches for gliomas Journal of translational medicine, 2010; 8(1): 100.

Kim Won, Liau Linda M   Dendritic cell vaccines for brain tumors Neurosurgery clinics of North America, 2010; 21(1): 139-57.

Lee Yohan, Liu Jason, Patel Shilpa, Cloughesy Timothy, Lai Albert, Farooqi Haumith, Seligson David, Dong Jun, Liau Linda, Becker Donald, Mischel Paul, Shams Soheil, Nelson Stanley   Genomic landscape of meningiomas Brain pathology (Zurich, Switzerland), 2010; 20(4): 751-62.

Cohen Joseph R, Resnick Daniel Z, Niewiadomski Pawel, Dong Hongmei, Liau Linda M, Waschek James A   Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures BMC cancer, 2010; 10(1): 676.

Veeriah Selvaraju, Taylor Barry S, Meng Shasha, Fang Fang, Yilmaz Emrullah, Vivanco Igor, Janakiraman Manickam, Schultz Nikolaus, Hanrahan Aphrothiti J, Pao William, Ladanyi Marc, Sander Chris, Heguy Adriana, Holland Eric C, Paty Philip B, Mischel Paul S, Liau Linda, Cloughesy Timothy F, Mellinghoff Ingo K, Solit David B, Chan Timothy A   Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies Nature genetics, 2010; 42(1): 77-82.

Kappadakunnel Melanie, Eskin Ascia, Dong Jun, Nelson Stanley F, Mischel Paul S, Liau Linda M, Ngheimphu Phioanh, Lai Albert, Cloughesy Timothy F, Goldin Jonathan, Pope Whitney B   Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone Journal of neuro-oncology, 2010; 96(3): 359-67.

Vivanco Igor, Rohle Daniel, Versele Matthias, Iwanami Akio, Kuga Daisuke, Oldrini Barbara, Tanaka Kazuhiro, Dang Julie, Kubek Sara, Palaskas Nicolaos, Hsueh Teli, Evans Michael, Mulholland David, Wolle Daniel, Rajasekaran Sigrid, Rajasekaran Ayyappan, Liau Linda M, Cloughesy Timothy F, Dikic Ivan, Brennan Cameron, Wu Hong, Mischel Paul S, Perera Timothy, Mellinghoff Ingo K   The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(14): 6459-64.

Du Jinyan, Bernasconi Paula, Clauser Karl R, Mani D R, Finn Stephen P, Beroukhim Rameen, Burns Melissa, Julian Bina, Peng Xiao P, Hieronymus Haley, Maglathlin Rebecca L, Lewis Timothy A, Liau Linda M, Nghiemphu Phioanh, Mellinghoff Ingo K, Louis David N, Loda Massimo, Carr Steven A, Kung Andrew L, Golub Todd R   Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy Nature biotechnology, 2009; 27(1): 77-83.

Dang Lenny, White David W, Gross Stefan, Bennett Bryson D, Bittinger Mark A, Driggers Edward M, Fantin Valeria R, Jang Hyun Gyung, Jin Shengfang, Keenan Marie C, Marks Kevin M, Prins Robert M, Ward Patrick S, Yen Katharine E, Liau Linda M, Rabinowitz Joshua D, Cantley Lewis C, Thompson Craig B, Vander Heiden Matthew G, Su Shinsan M   Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature, 2009; 462(7274): 739-44.

Liu Qinghai, Nguyen David H, Dong Qinghua, Shitaku Peter, Chung Kenneth, Liu On Ying, Tso Jonathan L, Liu Jason Y, Konkankit Veerauo, Cloughesy Timothy F, Mischel Paul S, Lane Timothy F, Liau Linda M, Nelson Stanley F, Tso Cho-Lea   Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors Journal of neuro-oncology, 2009; 94(1): 1-19.

Chang Edward F, Clark Aaron, Jensen Randy L, Bernstein Mark, Guha Abhijit, Carrabba Giorgio, Mukhopadhyay Debabrata, Kim Won, Liau Linda M, Chang Susan M, Smith Justin S, Berger Mitchel S, McDermott Michael W   Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical article Journal of neurosurgery, 2009; 111(2): 203-10.

Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I   Neurosphere formation is an independent predictor of clinical outcome in malignant glioma Stem cells (Dayton, Ohio), 2009; 27(4): 980-7.

McGillicuddy Lauren T, Fromm Jody A, Hollstein Pablo E, Kubek Sara, Beroukhim Rameen, De Raedt Thomas, Johnson Bryan W, Williams Sybil M G, Nghiemphu Phioanh, Liau Linda M, Cloughesy Tim F, Mischel Paul S, Parret Annabel, Seiler Jeanette, Moldenhauer Gerd, Scheffzek Klaus, Stemmer-Rachamimov Anat O, Sawyers Charles L, Brennan Cameron, Messiaen Ludwine, Mellinghoff Ingo K, Cichowski Karen   Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis Cancer cell, 2009; 16(1): 44-54.

Veeriah Selvaraju, Brennan Cameron, Meng Shasha, Singh Bhuvanesh, Fagin James A, Solit David B, Paty Philip B, Rohle Dan, Vivanco Igor, Chmielecki Juliann, Pao William, Ladanyi Marc, Gerald William L, Liau Linda, Cloughesy Timothy C, Mischel Paul S, Sander Chris, Taylor Barry, Schultz Nikolaus, Major John, Heguy Adriana, Fang Fang, Mellinghoff Ingo K, Chan Timothy A   The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(23): 9435-40.

Prins Robert M, Shu Chengyi J, Radu Caius G, Vo Dan D, Khan-Farooqi Haumith, Soto Horacio, Yang Meng-Yin, Lin Muh-Shi, Shelly Stephanie, Witte Owen N, Ribas Antoni, Liau Linda M   Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain Cancer immunology, immunotherapy : CII, 2008; 57(9): 1279-89.

Cloughesy Tim F, Yoshimoto Koji, Nghiemphu Phioanh, Brown Kevin, Dang Julie, Zhu Shaojun, Hsueh Teli, Chen Yinan, Wang Wei, Youngkin David, Liau Linda, Martin Neil, Becker Don, Bergsneider Marvin, Lai Albert, Green Richard, Oglesby Tom, Koleto Michael, Trent Jeff, Horvath Steve, Mischel Paul S, Mellinghoff Ingo K, Sawyers Charles L   Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma PLoS medicine, 2008; 5(1): e8.

Prins Robert M, Cloughesy Timothy F, Liau Linda M   Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate The New England journal of medicine, 2008; 359(5): 539-41.

Lelievre Vincent, Seksenyan Akop, Nobuta Hiroko, Yong William H, Chhith Seririthanar, Niewiadomski Pawel, Cohen Joseph R, Dong Hongmei, Flores Avegail, Liau Linda M, Kornblum Harley I, Scott Matthew P, Waschek James A   Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice Developmental biology, 2008; 313(1): 359-70.

Lee Yohan, Scheck Adrienne C, Cloughesy Timothy F, Lai Albert, Dong Jun, Farooqi Haumith K, Liau Linda M, Horvath Steve, Mischel Paul S, Nelson Stanley F   Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age BMC medical genomics, 2008; 1(1): 52.

Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I   Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells Journal of neuroscience research, 2008; 86(1): 48-60.

Lai Albert, Filka Emese, McGibbon Bruce, Nghiemphu Phioanh Leia, Graham Carrie, Yong William H, Mischel Paul, Liau Linda M, Bergsneider Marvin, Pope Whitney, Selch Michael, Cloughesy Tim   Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability International journal of radiation oncology, biology, physics, 2008; 71(5): 1372-80.

Pope Whitney B, Chen Jenny H, Dong Jun, Carlson Marc R J, Perlina Alla, Cloughesy Timothy F, Liau Linda M, Mischel Paul S, Nghiemphu Phioanh, Lai Albert, Nelson Stanley F   Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis Radiology, 2008; 249(1): 268-77.

Beroukhim Rameen, Getz Gad, Nghiemphu Leia, Barretina Jordi, Hsueh Teli, Linhart David, Vivanco Igor, Lee Jeffrey C, Huang Julie H, Alexander Sethu, Du Jinyan, Kau Tweeny, Thomas Roman K, Shah Kinjal, Soto Horacio, Perner Sven, Prensner John, Debiasi Ralph M, Demichelis Francesca, Hatton Charlie, Rubin Mark A, Garraway Levi A, Nelson Stan F, Liau Linda, Mischel Paul S, Cloughesy Tim F, Meyerson Matthew, Golub Todd A, Lander Eric S, Mellinghoff Ingo K, Sellers William R   Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(50): 20007-12.

Thomas Roman K, Baker Alissa C, Debiasi Ralph M, Winckler Wendy, Laframboise Thomas, Lin William M, Wang Meng, Feng Whei, Zander Thomas, MacConaill Laura, Macconnaill Laura E, Lee Jeffrey C, Nicoletti Rick, Hatton Charlie, Goyette Mary, Girard Luc, Majmudar Kuntal, Ziaugra Liuda, Wong Kwok-Kin, Gabriel Stacey, Beroukhim Rameen, Peyton Michael, Barretina Jordi, Dutt Amit, Emery Caroline, Greulich Heidi, Shah Kinjal, Sasaki Hidefumi, Gazdar Adi, Minna John, Armstrong Scott A, Mellinghoff Ingo K, Hodi F Stephen, Dranoff Glenn, Mischel Paul S, Cloughesy Tim F, Nelson Stan F, Liau Linda M, Mertz Kirsten, Rubin Mark A, Moch Holger, Loda Massimo, Catalona William, Fletcher Jonathan, Signoretti Sabina, Kaye Frederic, Anderson Kenneth C, Demetri George D, Dummer Reinhard, Wagner Stephan, Herlyn Meenhard, Sellers William R, Meyerson Matthew, Garraway Levi A   High-throughput oncogene mutation profiling in human cancer Nature genetics, 2007; 39(3): 347-51.

Carlson Marc R J, Pope Whitney B, Horvath Steve, Braunstein Jerome G, Nghiemphu Phioanh, Tso Cho-Lea, Mellinghoff Ingo, Lai Albert, Liau Linda M, Mischel Paul S, Dong Jun, Nelson Stanley F, Cloughesy Timothy F   Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2 Clinical cancer research : an official journal of the American Association for Cancer Research, 2007; 13(9): 2592-8.

Prins Robert M, Bruhn Kevin W, Craft Noah, Lin Jia Wei, Kim Choong-Hyun, Odesa Sylvia K, Miller Jeff F, Liau Linda M   Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden Neurosurgery, 2006; 58(1): 169-78; discussion 169-78.

Salgaller Michael L, Liau Linda M   Current status of clinical trials for glioblastoma Reviews on recent clinical trials, 2006; 1(3): 265-81.

Tso Cho-Lea, Freije William A, Day Allen, Chen Zugen, Merriman Barry, Perlina Ally, Lee Yohan, Dia Ederlyn Q, Yoshimoto Koji, Mischel Paul S, Liau Linda M, Cloughesy Timothy F, Nelson Stanley F   Distinct transcription profiles of primary and secondary glioblastoma subgroups Cancer research, 2006; 66(1): 159-67.

Lee Jeffrey C, Vivanco Igor, Beroukhim Rameen, Huang Julie H Y, Feng Whei L, DeBiasi Ralph M, Yoshimoto Koji, King Jennifer C, Nghiemphu Phioanh, Yuza Yuki, Xu Qing, Greulich Heidi, Thomas Roman K, Paez J Guillermo, Peck Timothy C, Linhart David J, Glatt Karen A, Getz Gad, Onofrio Robert, Ziaugra Liuda, Levine Ross L, Gabriel Stacey, Kawaguchi Tomohiro, O'Neill Keith, Khan Haumith, Liau Linda M, Nelson Stanley F, Rao P Nagesh, Mischel Paul, Pieper Russell O, Cloughesy Tim, Leahy Daniel J, Sellers William R, Sawyers Charles L, Meyerson Matthew, Mellinghoff Ingo K   Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain PLoS medicine, 2006; 3(12): e485.

Yang Meng-Yin, Zetler Paul M, Prins Robert M, Khan-Farooqi Haumith, Liau Linda M   Immunotherapy for patients with malignant glioma: from theoretical principles to clinical applications Expert review of neurotherapeutics, 2006; 6(10): 1481-94.

Prins Robert M, Vo Dan D, Khan-Farooqi Haumith, Yang Meng-Yin, Soto Horacio, Economou James S, Liau Linda M, Ribas Antoni   NK and CD4 cells collaborate to protect against melanoma tumor formation in the brain Journal of immunology (Baltimore, Md. : 1950), 2006; 177(12): 8448-55.

Tso Cho-Lea, Shintaku Peter, Chen James, Liu Qinghai, Liu Jason, Chen Zugen, Yoshimoto Koji, Mischel Paul S, Cloughesy Timothy F, Liau Linda M, Nelson Stanley F   Primary glioblastomas express mesenchymal stem-like properties Molecular cancer research : MCR, 2006; 4(9): 607-19.

Lasky Joseph L, Liau Linda M   Targeting stem cells in brain tumors Technology in cancer research & treatment, 2006; 5(3): 251-60.

Prins Robert M, Craft Noah, Bruhn Kevin W, Khan-Farooqi Haumith, Koya Richard C, Stripecke Renata, Miller Jeff F, Liau Linda M   The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity Journal of immunology (Baltimore, Md. : 1950), 2006; 176(1): 157-64.

Craft Noah, Bruhn Kevin W, Nguyen Bidong D, Prins Robert, Liau Linda M, Collisson Eric A, De Abhijit, Kolodney Michael S, Gambhir Sanjiv S, Miller Jeff F   Bioluminescent imaging of melanoma in live mice The Journal of investigative dermatology, 2005; 125(1): 159-65.

Liau Linda M, Prins Robert M, Kiertscher Sylvia M, Odesa Sylvia K, Kremen Thomas J, Giovannone Adrian J, Lin Jia-Wei, Chute Dennis J, Mischel Paul S, Cloughesy Timothy F, Roth Michael D   Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment Clinical cancer research : an official journal of the American Association for Cancer Research, 2005; 11(15): 5515-25.

Boudreau Christine R, Yang Isaac, Liau Linda M   Gliomas: advances in molecular analysis and characterization Surgical neurology, 2005; 64(4): 286-94; discussion 294.

Chen Wei, Cloughesy Timothy, Kamdar Nirav, Satyamurthy Nagichettiar, Bergsneider Marvin, Liau Linda, Mischel Paul, Czernin Johannes, Phelps Michael E, Silverman Daniel H S   Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005; 46(6): 945-52.

Bergsneider Marvin, Sehati Nouzhan, Villablanca Pablo, McArthur David L, Becker Donald P, Liau Linda M   Mahaley Clinical Research Award: extent of glioma resection using low-field (0.2 T) versus high-field (1.5 T) intraoperative MRI and image-guided frameless neuronavigation Clinical neurosurgery, 2005; 52(1-2): 389-99.

Mellinghoff Ingo K, Wang Maria Y, Vivanco Igor, Haas-Kogan Daphne A, Zhu Shaojun, Dia Ederlyn Q, Lu Kan V, Yoshimoto Koji, Huang Julie H Y, Chute Dennis J, Riggs Bridget L, Horvath Steve, Liau Linda M, Cavenee Webster K, Rao P Nagesh, Beroukhim Rameen, Peck Timothy C, Lee Jeffrey C, Sellers William R, Stokoe David, Prados Michael, Cloughesy Timothy F, Sawyers Charles L, Mischel Paul S   Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors The New England journal of medicine, 2005; 353(19): 2012-24.

Mehrian Shai Ruty, Reichardt Juergen K V, Ya-Hsuan Hsu, Kremen Thomas J, Liau Linda M, Cloughesy Timothy F, Mischel Paul S, Nelson Stanley F   Robustness of gene expression profiling in glioma specimen samplings and derived cell lines Brain research. Molecular brain research, 2005; 136(1-2): 99-103.

Craft Noah, Bruhn Kevin W, Nguyen Bidong D, Prins Robert, Lin Jia Wei, Liau Linda M, Miller Jeffery F   The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine Journal of immunology (Baltimore, Md. : 1950), 2005; 175(3): 1983-90.

Khan-Farooqi Haumith R, Prins Robert M, Liau Linda M   Tumor immunology, immunomics and targeted immunotherapy for central nervous system malignancies Neurological research, 2005; 27(7): 692-702.

Prins Robert M, Liau Linda M   Cellular immunity and immunotherapy of brain tumors Frontiers in bioscience : a journal and virtual library, 2004; 9(18): 3124-36.

Freije William A, Castro-Vargas F Edmundo, Fang Zixing, Horvath Steve, Cloughesy Timothy, Liau Linda M, Mischel Paul S, Nelson Stanley F   Gene expression profiling of gliomas strongly predicts survival Cancer research, 2004; 64(18): 6503-10.

Yang Isaac, Kremen Thomas J, Giovannone Adrian J, Paik Elena, Odesa Sylvia K, Prins Robert M, Liau Linda M   Modulation of major histocompatibility complex Class I molecules and major histocompatibility complex-bound immunogenic peptides induced by interferon-alpha and interferon-gamma treatment of human glioblastoma multiforme Journal of neurosurgery, 2004; 100(2): 310-9.

Boudreau Christine R, Liau Linda M   Molecular characterization of brain tumors Clinical neurosurgery, 2004; 51(2): 81-90.

Wang Yinglin, Zhu Shaojun, Cloughesy Timothy F, Liau Linda M, Mischel Paul S   p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition Oncogene, 2004; 23(6): 1283-90.

Shai Ruty, Shi Tao, Kremen Thomas J, Horvath Steve, Liau Linda M, Cloughesy Timothy F, Mischel Paul S, Nelson Stanley F   Gene expression profiling identifies molecular subtypes of gliomas Oncogene, 2003; 22(31): 4918-23.

Mischel Paul S, Shai Ruty, Shi Tao, Horvath Steve, Lu Kan V, Choe Gheeyoung, Seligson David, Kremen Thomas J, Palotie Aarno, Liau Linda M, Cloughesy Timothy F, Nelson Stanley F   Identification of molecular subtypes of glioblastoma by gene expression profiling Oncogene, 2003; 22(15): 2361-73.

Prins Robert M, Liau Linda M   Immunology and immunotherapy in neurosurgical disease Neurosurgery, 2003; 53(1): 144-52; discussion 152-3.

Prins Robert M, Odesa Sylvia K, Liau Linda M   Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model Cancer research, 2003; 63(23): 8487-91.

Broder Howard, Anderson Andrea, Kremen Thomas J, Odesa Sylvia K, Liau Linda M   MART-1 adenovirus-transduced dendritic cell immunization in a murine model of metastatic central nervous system tumor Journal of neuro-oncology, 2003; 64(1-2): 21-30.

Choe Gheeyoung, Park Jun K, Jouben-Steele Lisa, Kremen Thomas J, Liau Linda M, Vinters Harry V, Cloughesy Timothy F, Mischel Paul S   Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype Clinical cancer research : an official journal of the American Association for Cancer Research, 2002; 8(9): 2894-901.

Liau Linda M, Jensen Eric R, Kremen Thomas J, Odesa Sylvia K, Sykes Steven N, Soung Michael C, Miller Jeff F, Bronstein Jeff M   Tumor immunity within the central nervous system stimulated by recombinant Listeria monocytogenes vaccination Cancer research, 2002; 62(8): 2287-93.

Yamada Kazunari, Tso Jonathan, Ye Fei, Choe Jinny, Liu Yue, Liau Linda M, Tso Cho-Lea   Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence Cancers, 2011; 3(2): 1975-95.

Harris Robert J, Bookheimer Susan Y, Cloughesy Timothy F, Kim Hyun J, Pope Whitney B, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Ellingson Benjamin M   Altered functional connectivity of the default mode network in diffuse gliomas measured with pseudo-resting state fMRI Journal of neuro-oncology, 2013; 8(11): .

Zhukova Nataliya, Ramaswamy Vijay, Remke Marc, Pfaff Elke, Shih David J H, Martin Dianna C, Castelo-Branco Pedro, Baskin Berivan, Ray Peter N, Bouffet Eric, von Bueren André O, Jones David T W, Northcott Paul A, Kool Marcel, Sturm Dominik, Pugh Trevor J, Pomeroy Scott L, Cho Yoon-Jae, Pietsch Torsten, Gessi Marco, Rutkowski Stefan, Bognar Laszlo, Klekner Almos, Cho Byung-Kyu, Kim Seung-Ki, Wang Kyu-Chang, Eberhart Charles G, Fevre-Montange Michelle, Fouladi Maryam, French Pim J, Kros Max, Grajkowska Wieslawa A, Gupta Nalin, Weiss William A, Hauser Peter, Jabado Nada, Jouvet Anne, Jung Shin, Kumabe Toshihiro, Lach Boleslaw, Leonard Jeffrey R, Rubin Joshua B, Liau Linda M, Massimi Luca, Pollack Ian F, Shin Ra Young, Van Meir Erwin G, Zitterbart Karel, Schüller Ulrich, Hill Rebecca M, Lindsey Janet C, Schwalbe Ed C, Bailey Simon, Ellison David W, Hawkins Cynthia, Malkin David, Clifford Steven C, Korshunov Andrey, Pfister Stefan, Taylor Michael D, Tabori Uri   Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013; 31(23): 2927-35.

Woodworth Davis C, Pope Whitney B, Liau Linda M, Kim Hyun J, Lai Albert, Nghiemphu Phioanh L, Cloughesy Timothy F, Ellingson Benjamin M   Nonlinear distortion correction of diffusion MR images improves quantitative DTI measurements in glioblastoma Journal of neuro-oncology, 2013; .

Chen Walter W, Balaj Leonora, Liau Linda M, Samuels Michael L, Kotsopoulos Steve K, Maguire Casey A, Loguidice Lori, Soto Horacio, Garrett Matthew, Zhu Lin Dan, Sivaraman Sarada, Chen Clark, Wong Eric T, Carter Bob S, Hochberg Fred H, Breakefield Xandra O, Skog Johan   BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles Molecular therapy. Nucleic acids, 2013; 2(23): e109.

Remke Marc, Ramaswamy Vijay, Peacock John, Shih David J H, Koelsche Christian, Northcott Paul A, Hill Nadia, Cavalli Florence M G, Kool Marcel, Wang Xin, Mack Stephen C, Barszczyk Mark, Morrissy A Sorana, Wu Xiaochong, Agnihotri Sameer, Luu Betty, Jones David T W, Garzia Livia, Dubuc Adrian M, Zhukova Nataliya, Vanner Robert, Kros Johan M, French Pim J, Van Meir Erwin G, Vibhakar Rajeev, Zitterbart Karel, Chan Jennifer A, Bognár László, Klekner Almos, Lach Boleslaw, Jung Shin, Saad Ali G, Liau Linda M, Albrecht Steffen, Zollo Massimo, Cooper Michael K, Thompson Reid C, Delattre Oliver O, Bourdeaut Franck, Doz François F, Garami Miklós, Hauser Peter, Carlotti Carlos G, Van Meter Timothy E, Massimi Luca, Fults Daniel, Pomeroy Scott L, Kumabe Toshiro, Ra Young Shin, Leonard Jeffrey R, Elbabaa Samer K, Mora Jaume, Rubin Joshua B, Cho Yoon-Jae, McLendon Roger E, Bigner Darell D, Eberhart Charles G, Fouladi Maryam, Wechsler-Reya Robert J, Faria Claudia C, Croul Sidney E, Huang Annie, Bouffet Eric, Hawkins Cynthia E, Dirks Peter B, Weiss William A, Schüller Ulrich, Pollack Ian F, Rutkowski Stefan, Meyronet David, Jouvet Anne, Fèvre-Montange Michelle, Jabado Nada, Perek-Polnik Marta, Grajkowska Wieslawa A, Kim Seung-Ki, Rutka James T, Malkin David, Tabori Uri, Pfister Stefan M, Korshunov Andrey, von Deimling Andreas, Taylor Michael D   TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma Acta neuropathologica, 2013; 126(6): 917-29.

Papour Asael, Taylor Zach, Sherman Adria, Sanchez Desiree, Lucey Gregory, Liau Linda, Stafsudd Oscar, Yong William, Grundfest Warren   Optical imaging for brain tissue characterization using relative fluorescence lifetime imaging Journal of biomedical optics, 2013; 18(6): 60504.

Ye Fei, Zhang Yibei, Liu Yue, Yamada Kazunari, Tso Jonathan L, Menjivar Jimmy C, Tian Jane Y, Yong William H, Schaue Dörthe, Mischel Paul S, Cloughesy Timothy F, Nelson Stanley F, Liau Linda M, McBride William, Tso Cho-Lea   Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence PloS one, 2013; 8(11): e80397.