Kaufman, Daniel

Login to edit your profile page

Titles

Professor, Molecular & Medical Pharmacology

Member, Brain Research Institute

Immunity, Microbes & Molecular Pathogenesis GPB Home Area

Molecular Pharmacology GPB Home Area

Neuroscience GPB Home Area

Contact Information

Email
dkaufman@mednet.ucla.edu
Phone
Lab Number: 310-206-3350
Office Phone Number: 310-794-9664
Address

Laboratory Address:

Laboratory
23-167 CHS
Los Angeles, CA 90095
UNITED STATES

Office Address:

Office
23-167 CHS
Los Angeles, CA 90095
UNITED STATES

Website
https://www.uclaaccess.ucla.edu/Faculty.aspx?rv_FacultyId=1366

Publications

A selected list of publications:

Tian J, Dang H, Middleton B, Kaufman DL.   Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication, Scientific Reports, 2017; .
Download
Jide Tian, Hoa Dang, Angela Hu, Willem Xu, and Daniel L. Kaufman   Repurposing lesogaberan to promote human islet-cell survival and ß-cell replication, J. Diab. Res, 2017; in press: .
Tian, J., Dang, H., Nguyen, A.V., Chen, Z, Kaufman, DL   Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T cell autoimmunity and promoting ß-cell replication in newly diabetic NOD mice, Diabetes, 2014; 63: 3128-3134.
Laćan Goran, Dang Hoa, Middleton Blake, Horwitz Marcus A, Tian Jide, Melega William P, Kaufman Daniel L   Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Journal of neuroscience research, 2013; .
Tian Jide, Dang Hoa, Chen Zheying, Guan Alice, Jin Yingli, Atkinson Mark A, Kaufman Daniel L   GABA regulates both the survival and replication of human ss-cells Diabetes, 2013; .
Bilousova Tina, Dang Hoa, Xu Willem, Gustafson Sarah, Jin Yingli, Wickramasinghe Lalinda, Won Tony, Bobarnac Gabriela, Middleton Blake, Tian Jide, Kaufman Daniel L   Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization Journal of Neuroimmunology, 2012; 247(1-2): 1-8.
Tian Jide, Yong Jing, Dang Hoa, Kaufman Daniel L   Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis Autoimmunity, 2011; 44(6): 465-70.
Washburn, L.R., Zekzer, D., Eitan, S., Lu, Y., Dang, H., Middleton, B., Evans, C.J., Tian, J., Kaufman, D.L.   A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth. , PLoS ONE, 2011; e18439: .
Download
Yong, J., Lacan, G., Dang, H., Hsieh, T., Middleton, B., Wasserfall, C., Tian, J., Melega, W.P., Kaufman, D.L.   BCG vaccine-induced neuroprotection in a mouse model of Parkinson's Disease, PLoS ONE, 2011; 6(1):e16610. PMCID: PMC3031604: .
Tian, J., Dang, H., Kaufman D.L   Combining Antigen-Based Therapy with GABA Treatment Synergistically Prolongs Survival of Transplanted ß-Cells in Diabetic NOD Mice, PLoS ONE, 2011; e25337: .
Download
Wu ZP, Washburn L, Bilousova TV, Boudzinskaia M, Escande-Beillard N, Querubin J, Dang H, Xie CW, Tian J, Kaufman DL   Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair, J Neuroimmunol, 2011; 232: 8-16.
Wu ZP, Bilousova T, Dang H, Hsieh T, Tian J, Kaufman DL   Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves, Immunol Lett, 2011; 135: 118-123.
Yong, J., Rasooly, J., Dang, H,, Lu, Y., Middleton, B., Zhang, Z., Hon, L., Namavari, M., Stout, D., Atkinson, M.A., Tian, J., Gambhir, S.S., Kaufman, D.L   Multimodality Imaging of ß-cells in Mouse Models of Type I and II Diabetes, Diabetes, 2011; 60: 1383-1392 .
Download
Tian, J., Young, J, Dang H., and Kaufman DL.   Oral GABA treatment down-regulates inflammatory responses in a mouse model of rheumatoid arthritis, Autoimmunity, 2011; 44 : 465-470.
Download
Tian, J., Dang, H.N., Yong, J., Chui W-S, Dizon, M.P.G., Yaw, C.K.Y. Kaufman, D.L   Oral Treatment with γ-Aminobutyric Acid Improves Glucose Tolerance and Insulin Sensitivity by Inhibiting Inflammation in High Fat Diet-Fed Mice, PLoS ONE, 2011; e25338: .
Joseph, S.M., Wu, Z-P, Zdunowski, S., Middleton, B., Boudzinskaia, M, Wong, B., Ali, N., Zhong, H., Yong, J., Washburn, L., Escande-Beillard, N., Dang, N., Edgerton, V.R., Tillakaratne. N.J.K., Kaufman, D.L.,   Transgenic mice with enhanced neuronal MHC class I expression recover locomotor function better after spinal cord injury, J Neurosci Res, 2011; 89: 365-372.
Washburn Lorraine R, Zekzer Dan, Eitan Shoshana, Lu Yuxin, Dang Hoa, Middleton Blake, Evans Christopher J, Tian Jide, Kaufman Daniel L   A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth PloS one, 2011; 6(3): e18439.
Yong Jing, Rasooly Julia, Dang Hoa, Lu Yuxin, Middleton Blake, Zhang Zesong, Hon Larry, Namavari Mohammad, Stout David B, Atkinson Mark A, Tian Jide, Gambhir Sanjiv Sam, Kaufman Daniel L   Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes Diabetes, 2011; 60(5): 1383-92.
Yong Jing, Lacan Goran, Dang Hoa, Hsieh Terry, Middleton Blake, Wasserfall Clive, Tian Jide, Melega William P, Kaufman Daniel L   BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease PloS one, 2011; 6(1): e16610.
Tian Jide, Dang Hoa, Kaufman Daniel L   Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice PloS one, 2011; 6(9): e25337.
Wu Zhongqi-Phyllis, Washburn Lorraine, Bilousova Tina V, Boudzinskaia Maia, Escande-Beillard Nathalie, Querubin Jyes, Dang Hoa, Xie Cui-Wei, Tian Jide, Kaufman Daniel L   Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair Journal of neuroimmunology, 2011; 232(1-2): 8-16.
Wu Zhongqi-Phyllis, Bilousova Tina, Escande-Beillard Nathalie, Dang Hoa, Hsieh Terry, Tian Jide, Kaufman Daniel L   Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves Immunology letters, 2011; 135(1-2): 118-23.
Tian Jide, Dang Hoa N, Yong Jing, Chui Wing-Sheung, Dizon Matthew P G, Yaw Catherine K Y, Kaufman Daniel L   Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice PloS one, 2011; 6(9): e25338.
Joseph M Selvan, Bilousova Tina, Zdunowski Sharon, Wu Zhongqi-Phyllis, Middleton Blake, Boudzinskaia Maia, Wong Bonnie, Ali Noore, Zhong Hui, Yong Jing, Washburn Lorraine, Escande-Beillard Nathalie, Dang Hoa, Edgerton V Reggie, Tillakaratne Niranjala J K, Kaufman Daniel L   Transgenic mice with enhanced neuronal major histocompatibility complex class I expression recover locomotor function better after spinal cord injury Journal of neuroscience research, 2011; 89(3): 365-72.
Escande-Beillard, N., Washburn, L., Zekzer, D., Wu, Z-P., , Eitan, S., Ivkovic, S., Lu, Y., Dang, H., Middleton, B., Yoshimura, Y., Evans, C.J., Joyce, S., Tian, J., and Kaufman, D.L.   Neurons preferentially respond to self-major histocompatibility complex class I allele products regardless of peptide presented, J. Immunol, 2010; 184: 816-823.
Escande-Beillard Nathalie, Washburn Lorraine, Zekzer Dan, Wu Zhongqi-Phyllis, Eitan Shoshy, Ivkovic Sonja, Lu Yuxin, Dang Hoa, Middleton Blake, Bilousova Tina V, Yoshimura Yoshitaka, Evans Christopher J, Joyce Sebastian, Tian Jide, Kaufman Daniel L   Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented Journal of immunology (Baltimore, Md. : 1950), 2010; 184(2): 816-23.
Tian Jide, Dang Hoa, von Boehmer Harald, Jaeckel Elmar, Kaufman Daniel L   Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens Diabetes, 2009; 58(12): 2843-50.
Tian Jide, Kaufman Daniel L   Antigen-based therapy for the treatment of type 1 diabetes Diabetes, 2009; 58(9): 1939-46.
Tian J, Kaufman DL   Antigen-based therapy for the treatment of type 1 diabetes Diabetes, 2009; 58: 1939-1946.
Tian, J., Dang, H., von Boehmer, H., Jaeckel, E., Kaufman, D.L   Transgenically-induced GAD tolerance curtails the development of early ß-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other ß-cell antigens, Diabetes, 2009; Dec.: .
L.R. Washburn, H. Dang, J. Tian, D.L. Kaufman.   The postnatal maternal environment influences diabetes development in nonobese diabetic mice, J. Autoimmunity, 2007; 28: 19-23.
Lu Yuxin, Dang Hoa, Middleton Blake, Campbell-Thompson Martha, Atkinson Mark A, Gambhir Sanjiv Sam, Tian Jide, Kaufman Daniel L   Long-term monitoring of transplanted islets using positron emission tomography Molecular therapy : the journal of the American Society of Gene Therapy, 2006; 14(6): 851-6.
Lu, Y Dang, H Middleton, B Campbell-Thompson, M Atkinson, MA Gambhir, SS Tian, J Kaufman, DL   Long-term monitoring of transplanted islets using positron emission tomography Molecular therapy : the journal of the American Society of Gene Therapy, 2006; 14(6): 851-6.
Tian, J., Zekzer, D., Lu, Y., Dang, H.and Kaufman, DL.   B cells are crucial for determinant spreading of T cell autoimmunity among b-cell antigens in diabetes-prone NOD mice, Journal of Immunology, 2006; 176: 2654-2661.
Lu, Y., Dang, H., Middleton, B., Zhang, Z., Washburn, L., Stout, D.B., Campbell-Thompson, M., Atkinson, M.A., Phelps, M., Gambhir, S.S, Tian, J., and Kaufman, D.L.   Noninvasive imaging of islet grafts using positron emission tomography, PNAS, 2006; 103: 11294-11299.
Tian Jide, Zekzer Dan, Lu Yuxin, Dang Hoa, Kaufman Daniel L   B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice Journal of immunology (Baltimore, Md. : 1950), 2006; 176(4): 2654-61.
Olcott, A.P., Tian, J., Walker, V., Dang, H., Middleton, B., Adorini, L. Washburn, and Kaufman, D.L   Antigen-based therapies utilizing ignored determinants of beta-cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice, J. Immunol, 2005; 175: 1991-1999.
Tian, J Lu, Y Zhang, H Chau, CH Dang, HN Kaufman, DL   Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model Journal of immunology (Baltimore, Md. : 1950) , 2004; 173(8): 5298-304.
Olcott, AP Tocco, G Tian, J Zekzer, D Fukuto, J Ignarro, L Kaufman, DL   A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection Diabetes. , 2004; 53(10): 2574-80.
Lu, Y Dang, H Middleton, B Zhang, Z Washburn, L Campbell-Thompson, M Atkinson, MA Gambhir, SS Tian, J Kaufman, DL   Bioluminescent monitoring of islet graft survival after transplantation Molecular therapy : the journal of the American Society of Gene Therapy. , 2004; 9(3): 428-35.
Tian, J Lu, Y Hanssen, L Dang, H Kaufman, DL   Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens Cellular immunology. , 2003; 224(2): 74-85.
Kaufman, DL   Murder mysteries in type 1 diabetes Nature medicine. , 2003; 9(2): 161-2.
Tian, J., Olcott A.P. and Kaufman, D.L.   Antigen-based immunotherapy drives the precocious developement of autoimmunity, J. Immunol, 2002; 169: 6564-6569.
Kaufman, D.L and Tobin, A.J.   Glutamic Acid Decarboxylases: Insights into Neural Signaling and Autoimmune Diabetes, Encyclopedia of Molecular Medicine , 2002; 1459-1462.
Kaufman, DL Tisch, R Sarvetnick, N Chatenoud, L Harrison, LC Haskins, K Quinn, A Sercarz, E Singh, B von Herrath, M Wegmann, D Wen, L Zekzer, D   Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop Diabetes. , 2001; 50(11): 2459-63.
Kaufman, D.L and Tobin, A.J.   Glutamic Acid Decarboxylases: Insights into Neural Signaling and Autoimmune Diabetes, Encyclopedia of Molecular Medicine, 2001; .
Jide Tian and Daniel Kaufman.   Lipopolysacharide-activated B cells as immunotherapy in NOD mice , J. Immunology , , 2001; 167: 1081-1089.
Jide Tian, Silvia Gregori, Luciano Aldorini and Daniel L. Kaufman.   The frequency of high avidity T cells determines the chronology of determinant spreading, J. Immunology, 2001; 166: 7144-7150.
Jide Tian and Daniel L. Kaufman   Control of Autoimmune Diabetes. (commentary), Science, 2000; 287: 191a.
Rocha, L Ondarza, R Kaufman, DL   Antisense oligonucleotides to C-fos reduce postictal seizure susceptibility following fully kindled seizures in rats Neuroscience letters. , 1999; 268(3): 143-6.
Tian et al.   Antigen-based Immunotherapy: From Animal Models to Man?, Immunology Today, 1999; 20: 190-195.
Tian, J, et al.   GABA-A receptors mediate inhbition of T cell responses, J. Neuroimmunology, 1999; 96: 21-28.
Tian, J Kaufman, DL   Attenuation of inducible Th2 immunity with autoimmune disease progression Journal of immunology (Baltimore, Md. : 1950) , 1998; 161(10): 5399-403.
Kranzler, HR Gelernter, J O'Malley, S Hernandez-Avila, CA Kaufman, D   Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1) Alcoholism, clinical and experimental research. , 1998; 22(6): 1359-62.
Tian, J Olcott, AP Hanssen, LR Zekzer, D Middleton, B Kaufman, DL   Infectious Th1 and Th2 autoimmunity in diabetes-prone mice Immunological reviews. , 1998; 164: 119-27.
Tian J. et al.   Selective priming of Th2 cells and induction of active tolerance in pre-diabetic mice by administration of soluble insulin Diabetologia, 1998; 41: 237-240.
Rocha, L Kaufman, DL   In vivo administration of c-Fos antisense oligonucleotides accelerates amygdala kindling Neuroscience letters. , 1998; 241(2-3): 111-4.
Tian, J Lehmann, PV Kaufman, DL   Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens The Journal of experimental medicine. , 1997; 186(12): 2039-43.
Tian, J Clare-Salzler, M Herschenfeld, A Middleton, B Newman, D Mueller, R Arita, S Evans, C Atkinson, MA Mullen, Y Sarvetnick, N Tobin, AJ Lehmann, PV Kaufman, DL   Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice Nature medicine. , 1996; 2(12): 1348-53.
Olcott, A.P., Tian, J. and Kaufman, D.L.   Autoantigen-based immunotherapy for human IDDM, Diabetes Prevention and Therapy , 1996; 10: 20-21.
Kaufman DL   GAD autoantibodies In: Autoantibody Textbook, 1996; 308-313.
Kaufman DL and Tobin AJ.   Glutamate decarboxylase, GABA and autoimmunity In: GABA receptors, transporters and metabolism, 1996; 23-30.
Tian, J., et al.   Nasal administration of glutamate decaboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes, J. Exp. Med, 1996; 183: 1561-1567.
Kaufman, DL Keith, DE Anton, B Tian, J Magendzo, K Newman, D Tran, TH Lee, DS Wen, C Xia, YR   Characterization of the murine mu opioid receptor gene The Journal of biological chemistry. , 1995; 270(26): 15877-83.
Atkinson MA et al.   Cellular immunity to an epitope common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes J. Clin. Invest, 1994; 94: 2125-2129.
Tian et al.   T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is assocaited with a murine diabetes susceptability allele J. Exp. Med, 1994; 180: 1979-1984.
Kaufman DL and Tobin AJ.   Glutamate decaroxylases in insulin-dependent diabetes Trends in Pharmacological Sciences, 1993; 14: 107-109.
Atkinson et al.   Islet cell autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes, J. Clinical. Invest. , 1993; 91, : 350-355.
Kaufman, D.L., et al.   Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes, Nature, 1993; 366: 69-72.
Atkinson, M.A.et al.   Peripheral blood mononuclear cells respond to glutamate decarboxylase in insulin-dependent diabetes, Lancet, 1992; 339: 458-459.
  Tian, J., Dang, H., Wallner, M., Olsen R., and Kaufman D.L. Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis, Sci. Reports in press, 2018; .