Black, Douglas


Professor, Microbiology, Immunology & Molecular Genetics

Contact Information

Lab Number: (310) 794-7689
Office Phone Number: (310) 794-7644

Laboratory Address:

MRL 6-567


Work Address:

MRL 6-780
CAMPUS - 951489


A selected list of publications:

Damianov Andrey, Ying Yi, Lin Chia-Ho, Lee Ji-Ann, Tran Diana, Vashisht Ajay A, Bahrami-Samani Emad, Xing Yi, Martin Kelsey C, Wohlschlegel James A, Black Douglas L   Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR Cell, 2016; 165(3): 606-19.
Vuong Celine K, Black Douglas L, Zheng Sika   The neurogenetics of alternative splicing Nature reviews. Neuroscience, 2016; 17(5): 265-81.
Linares Anthony J, Lin Chia-Ho, Damianov Andrey, Adams Katrina L, Novitch Bennett G, Black Douglas L   The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation eLife, 2015; 4(1): e09268.
Sharma Shalini, Wongpalee Somsakul Pop, Vashisht Ajay, Wohlschlegel James A, Black Douglas L   Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly Genes & development, 2014; 28(22): 2518-31.
Li Qin, Zheng Sika, Han Areum, Lin Chia-Ho, Stoilov Peter, Fu Xiang-Dong, Black Douglas L   The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation eLife, 2014; 3(22): e01201.
Zheng Sika, Damoiseaux Robert, Chen Liang, Black Douglas L   A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing Genome research, 2013; 23(6): 998-1007.
Pandya-Jones Amy, Bhatt Dev M, Lin Chia-Ho, Tong Ann-Jay, Smale Stephen T, Black Douglas L   Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression RNA (New York, N.Y.), 2013; 19(6): 811-27.
Zheng Sika, Gray Erin E, Chawla Geetanjali, Porse Bo Torben, O'Dell Thomas J, Black Douglas L   PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2 Nature neuroscience, 2012; 15(3): 381-8, S1.
Gehman Lauren T, Meera Pratap, Stoilov Peter, Shiue Lily, O'Brien Janelle E, Meisler Miriam H, Ares Manuel, Otis Thomas S, Black Douglas L   The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function Genes & development, 2012; 26(5): 445-60.
Bhatt Dev M, Pandya-Jones Amy, Tong Ann-Jay, Barozzi Iros, Lissner Michelle M, Natoli Gioacchino, Black Douglas L, Smale Stephen T   Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions Cell, 2012; 150(2): 279-90.
Gehman Lauren T, Stoilov Peter, Maguire Jamie, Damianov Andrey, Lin Chia-Ho, Shiue Lily, Ares Manuel, Mody Istvan, Black Douglas L   The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain Nature genetics, 2011; 43(7): 706-11.
Sharma Shalini, Maris Christophe, Allain Frédéric H-T, Black Douglas L   U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repression Molecular cell, 2011; 41(5): 579-88.
Lee Ji-Ann, Tang Zhen-Zhi, Black Douglas L   An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons Genes & development, 2009; 23(19): 2284-93.
Li, Qin, Lee, Ji-Ann, and Douglas L. Black   Neuronal Regulation of Alternative Pre-messenger RNA Splicing, Nature Reviews Neuroscience, 2007; 8(11): 819-31.
Boutz P, Stoilov P, Li Q, Lin C, Chawla G, Ostrow K, Shiue L, Manuel C. Ares and Douglas L. Black   Post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons, Genes and Development, 2007; 21(13): 1636-52.
Underwood J, Boutz P, Dougherty JD, Stoilov P, Black DL   Homologues of the C. Elegans Fox-1 Protein are neuronal splicing regulators in mammals, MCB, 2005; 25(22): 10005-16.
Black DL   Mechanisms of alternative pre-messenger RNA splicing Annual review of biochemistry. , 2003; 72: 291-336.