Bhaduri, Aparna


Assistant Professor, Biological Chemistry

Contact Information



Dr. Aparna Bhaduri earned a B.S in Biochemistry and Cell Biology and a B.A in Political Science from Rice University in 2010. She completed her doctoral studies at Stanford University in Cancer Biology in 2016, where she focused on epithelial tissue differentiation and neoplasms She was a postdoctoral scholar at the University of California San Francisco in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, in the lab of Dr. Arnold Kriegstein. As a postdoctoral scholar, she has used single-cell RNA sequencing to characterize cell types in the developing cortex across cortical areas, in human and non-human primates, and in glioblastoma. Because experimental manipulations of the developing human cortex will require in vitro models, she has been using similar approaches to compare cells types in organoid models and primary tissues. Her long term interests to be pursued in her own independent laboratory at UCLA are in understanding how stem cells during cortical development give rise to the human brain, and how aspects of these developmental programs can be hijacked in cancers such as glioblastoma. One aspect of normal development and cancer that particularly interests her is the role of metabolism in regulating cell fate and tissue homeostasis. In order to explore these questions, Aparna uses single-cell genomics, informatic analysis, and organoid models. In her free time, she enjoys spending time with her husband rock climbing, biking, and cooking.


A selected list of publications:

Huang Wei, Bhaduri Aparna, Velmeshev Dmitry, Wang Shaohui, Wang Li, Rottkamp Catherine A, Alvarez-Buylla Arturo, Rowitch David H, Kriegstein Arnold R   Origins and Proliferative States of Human Oligodendrocyte Precursor Cells Cell, 2020; 182(3): 594-608.e11.
Ji Andrew L, Rubin Adam J, Thrane Kim, Jiang Sizun, Reynolds David L, Meyers Robin M, Guo Margaret G, George Benson M, Mollbrink Annelie, Bergenstråhle Joseph, Larsson Ludvig, Bai Yunhao, Zhu Bokai, Bhaduri Aparna, Meyers Jordan M, Rovira-Clavé Xavier, Hollmig S Tyler, Aasi Sumaira Z, Nolan Garry P, Lundeberg Joakim, Khavari Paul A   Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma Cell, 2020; 182(2): 497-514.e22.
Zhang Yue, Liu Guoping, Guo Teng, Liang Xiaoyi G, Du Heng, Yang Lin, Bhaduri Aparna, Li Xiaosu, Xu Zhejun, Zhang Zhuangzhi, Li Zhenmeiyu, He Miao, Tsyporin Jeremiah, Kriegstein Arnold R, Rubenstein John L, Yang Zhengang, Chen Bin   Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog Cell reports, 2020; 30(13): 4490-4504.e4.
Bhaduri Aparna, Andrews Madeline G, Mancia Leon Walter, Jung Diane, Shin David, Allen Denise, Jung Dana, Schmunk Galina, Haeussler Maximilian, Salma Jahan, Pollen Alex A, Nowakowski Tomasz J, Kriegstein Arnold R   Cell stress in cortical organoids impairs molecular subtype specification Nature, 2020; 578(7793): 142-148.
Satterstrom F Kyle, Kosmicki Jack A, Wang Jiebiao, Breen Michael S, De Rubeis Silvia, An Joon-Yong, Peng Minshi, Collins Ryan, Grove Jakob, Klei Lambertus, Stevens Christine, Reichert Jennifer, Mulhern Maureen S, Artomov Mykyta, Gerges Sherif, Sheppard Brooke, Xu Xinyi, Bhaduri Aparna, Norman Utku, Brand Harrison, Schwartz Grace, Nguyen Rachel, Guerrero Elizabeth E, Dias Caroline, Dias Caroline, Dias Caroline, Betancur Catalina, Cook Edwin H, Gallagher Louise, Gill Michael, Sutcliffe James S, Thurm Audrey, Zwick Michael E, Børglum Anders D, State Matthew W, Cicek A Ercument, Talkowski Michael E, Cutler David J, Devlin Bernie, Sanders Stephan J, Roeder Kathryn, Daly Mark J, Buxbaum Joseph D   Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism Cell, 2020; 180(3): 568-584.e23.
Bhaduri Aparna, Di Lullo Elizabeth, Jung Diane, Müller Sören, Crouch Elizabeth Erin, Espinosa Carmen Sandoval, Ozawa Tomoko, Alvarado Beatriz, Spatazza Julien, Cadwell Cathryn René, Wilkins Grace, Velmeshev Dmitry, Liu Siyuan John, Malatesta Martina, Andrews Madeline Gail, Mostajo-Radji Mohammed Andres, Huang Eric Jinsheng, Nowakowski Tomasz Jan, Lim Daniel Amos, Diaz Aaron, Raleigh David Ronan, Kriegstein Arnold Richard   Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma Cell stem cell, 2020; 26(1): 48-63.e6.
Cadwell Cathryn R, Bhaduri Aparna, Mostajo-Radji Mohammed A, Keefe Matthew G, Nowakowski Tomasz J   Development and Arealization of the Cerebral Cortex Neuron, 2019; 103(6): 980-1004.
Schirmer Lucas, Velmeshev Dmitry, Holmqvist Staffan, Kaufmann Max, Werneburg Sebastian, Jung Diane, Vistnes Stephanie, Stockley John H, Young Adam, Steindel Maike, Tung Brian, Goyal Nitasha, Bhaduri Aparna, Mayer Simone, Engler Jan Broder, Bayraktar Omer A, Franklin Robin J M, Haeussler Maximilian, Reynolds Richard, Schafer Dorothy P, Friese Manuel A, Shiow Lawrence R, Kriegstein Arnold R, Rowitch David H   Neuronal vulnerability and multilineage diversity in multiple sclerosis Nature, 2019; 573(7772): 75-82.
Adorjan Istvan, Tyler Teadora, Bhaduri Aparna, Demharter Samuel, Finszter Cintia Klaudia, Bako Maria, Sebok Oliver Marcell, Nowakowski Tomasz J, Khodosevich Konstantin, Møllgård Kjeld, Kriegstein Arnold R, Shi Lei, Hoerder-Suabedissen Anna, Ansorge Olaf, Molnár Zoltán   Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing Journal of anatomy, 2019; 235(3): 543-554.
Miller Daniel J, Bhaduri Aparna, Sestan Nenad, Kriegstein Arnold   Shared and derived features of cellular diversity in the human cerebral cortex Current opinion in neurobiology, 2019; 56(7772): 117-124.
Velmeshev Dmitry, Schirmer Lucas, Jung Diane, Haeussler Maximilian, Perez Yonatan, Mayer Simone, Bhaduri Aparna, Goyal Nitasha, Rowitch David H, Kriegstein Arnold R   Single-cell genomics identifies cell type-specific molecular changes in autism Science (New York, N.Y.), 2019; 364(6441): 685-689.
Mayer Simone, Chen Jiadong, Velmeshev Dmitry, Mayer Andreas, Eze Ugomma C, Bhaduri Aparna, Cunha Carlos E, Jung Diane, Arjun Arpana, Li Emmy, Alvarado Beatriz, Wang Shaohui, Lovegren Nils, Gonzales Michael L, Szpankowski Lukasz, Leyrat Anne, West Jay A A, Panagiotakos Georgia, Alvarez-Buylla Arturo, Paredes Mercedes F, Nowakowski Tomasz J, Pollen Alex A, Kriegstein Arnold R   Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex Neuron, 2019; 102(1): 143-158.e7.
Pollen Alex A, Bhaduri Aparna, Andrews Madeline G, Nowakowski Tomasz J, Meyerson Olivia S, Mostajo-Radji Mohammed A, Di Lullo Elizabeth, Alvarado Beatriz, Bedolli Melanie, Dougherty Max L, Fiddes Ian T, Kronenberg Zev N, Shuga Joe, Leyrat Anne A, West Jay A, Bershteyn Marina, Lowe Craig B, Pavlovic Bryan J, Salama Sofie R, Haussler David, Eichler Evan E, Kriegstein Arnold R   Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution Cell, 2019; 176(4): 743-756.e17.
Kovalski Joanna R, Bhaduri Aparna, Zehnder Ashley M, Neela Poornima H, Che Yonglu, Wozniak Glenn G, Khavari Paul A   The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2 Molecular cell, 2019; 73(4): 830-844.e12.
Bhaduri Aparna, Nowakowski Tomasz J   Single-cell sequencing paints diverse pictures of the brain Nature, 2018; 563(7729): 38-39.
Bhaduri Aparna, Nowakowski Tomasz J, Pollen Alex A, Kriegstein Arnold R   Identification of cell types in a mouse brain single-cell atlas using low sampling coverage BMC biology, 2018; 16(1): 113.
Lee Carolyn S, Mah Angela, Aros Cody J, Lopez-Pajares Vanessa, Bhaduri Aparna, Webster Dan E, Kretz Markus, Khavari Paul A   Cancer-Associated Long Noncoding RNA SMRT-2 Controls Epidermal Differentiation The Journal of investigative dermatology, 2018; 138(6): 1445-1449.
Fiddes Ian T, Lodewijk Gerrald A, Mooring Meghan, Bosworth Colleen M, Ewing Adam D, Mantalas Gary L, Novak Adam M, van den Bout Anouk, Bishara Alex, Rosenkrantz Jimi L, Lorig-Roach Ryan, Field Andrew R, Haeussler Maximilian, Russo Lotte, Bhaduri Aparna, Nowakowski Tomasz J, Pollen Alex A, Dougherty Max L, Nuttle Xander, Addor Marie-Claude, Zwolinski Simon, Katzman Sol, Kriegstein Arnold, Eichler Evan E, Salama Sofie R, Jacobs Frank M J, Haussler David   Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis Cell, 2018; 173(6): 1356-1369.e22.
Nagy Alexandra, Bhaduri Aparna, Shahmarvand Nahid, Shahryari Jahanbanoo, Zehnder James L, Warnke Roger A, Mughal Tariq, Ali Siraj, Ohgami Robert S   Next-generation sequencing of idiopathic multicentric and unicentric Castleman disease and follicular dendritic cell sarcomas Blood advances, 2018; 2(5): 481-491.
Müller Sören, Kohanbash Gary, Liu S John, Alvarado Beatriz, Carrera Diego, Bhaduri Aparna, Watchmaker Payal B, Yagnik Garima, Di Lullo Elizabeth, Malatesta Martina, Amankulor Nduka M, Kriegstein Arnold R, Lim Daniel A, Aghi Manish, Okada Hideho, Diaz Aaron   Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment Genome biology, 2017; 18(1): 234.
Nowakowski Tomasz J, Bhaduri Aparna, Pollen Alex A, Alvarado Beatriz, Mostajo-Radji Mohammed A, Di Lullo Elizabeth, Haeussler Maximilian, Sandoval-Espinosa Carmen, Liu Siyuan John, Velmeshev Dmitry, Ounadjela Johain Ryad, Shuga Joe, Wang Xiaohui, Lim Daniel A, West Jay A, Leyrat Anne A, Kent W James, Kriegstein Arnold R   Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex Science (New York, N.Y.), 2017; 358(6368): 1318-1323.
Ozawa Michael G, Bhaduri Aparna, Chisholm Karen M, Baker Steven A, Ma Lisa, Zehnder James L, Luna-Fineman Sandra, Link Michael P, Merker Jason D, Arber Daniel A, Ohgami Robert S   A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016; 29(10): 1212-20.
Siprashvili Zurab, Webster Dan E, Johnston Danielle, Shenoy Rajani M, Ungewickell Alexander J, Bhaduri Aparna, Flockhart Ross, Zarnegar Brian J, Che Yonglu, Meschi Francesca, Puglisi Joseph D, Khavari Paul A   The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer Nature genetics, 2016; 48(1): 53-8.
Bhaduri Aparna, Ungewickell Alexander, Boxer Lisa D, Lopez-Pajares Vanessa, Zarnegar Brian J, Khavari Paul A   Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR Developmental cell, 2015; 35(4): 444-57.
Ungewickell Alexander, Bhaduri Aparna, Rios Eon, Reuter Jason, Lee Carolyn S, Mah Angela, Zehnder Ashley, Ohgami Robert, Kulkarni Shashikant, Armstrong Randall, Weng Wen-Kai, Gratzinger Dita, Tavallaee Mahkam, Rook Alain, Snyder Michael, Kim Youn, Khavari Paul A   Genomic analysis of mycosis fungoides and Sézary syndrome identifies recurrent alterations in TNFR2 Nature genetics, 2015; 47(9): 1056-60.
Lee Carolyn S, Bhaduri Aparna, Mah Angela, Johnson Whitney L, Ungewickell Alexander, Aros Cody J, Nguyen Christie B, Rios Eon J, Siprashvili Zurab, Straight Aaron, Kim Jinah, Aasi Sumaira Z, Khavari Paul A   Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma Nature genetics, 2014; 46(10): 1060-2.
Noderer William L, Flockhart Ross J, Bhaduri Aparna, Diaz de Arce Alexander J, Zhang Jiajing, Khavari Paul A, Wang Clifford L   Quantitative analysis of mammalian translation initiation sites by FACS-seq Molecular systems biology, 2014; 10(10): 748.
Lee Carolyn S, Ungewickell Alexander, Bhaduri Aparna, Qu Kun, Webster Dan E, Armstrong Randall, Weng Wen-Kai, Aros Cody J, Mah Angela, Chen Richard O, Lin Meihong, Sundram Uma, Chang Howard Y, Kretz Markus, Kim Youn H, Khavari Paul A   Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts Blood, 2012; 120(16): 3288-97.
Bhaduri Aparna, Qu Kun, Lee Carolyn S, Ungewickell Alexander, Khavari Paul A   Rapid identification of non-human sequences in high-throughput sequencing datasets Bioinformatics (Oxford, England), 2012; 28(8): 1174-5.
Morlacchi Pietro, Wilson William K, Xiong Quanbo, Bhaduri Aparna, Sttivend Diana, Kolesnikova Mariya D, Matsuda Seiichi P T   Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana Organic letters, 2009; 11(12): 2627-30.