Gandal, Michael

Titles

Assistant Professor, Psychiatry and Biobehavioral Sciences

Member, Bioinformatics GPB Home Area

Brain Research Institute

Genetics & Genomics GPB Home Area

Contact Information

Email
MGandal@mednet.ucla.edu
Phone
Work Phone Number: 310-794-2164

Biography

Michael Gandal, MD PhD, is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and the Semel Institute for Neuroscience and Human Behavior. The Gandal laboratory employs systems-level, functional genomic approaches in human brain to understand the neurobiological mechanisms underlying psychiatric disorders including autism, schizophrenia, and bipolar disorder.

Publications

A selected list of publications:

Gandal Michael J, Haney Jillian R, Parikshak Neelroop N, Leppa Virpi, Ramaswami Gokul, Hartl Chris, Schork Andrew J, Appadurai Vivek, Buil Alfonso, Werge Thomas M, Liu Chunyu, White Kevin P, White Kevin P, White Kevin P, White Kevin P, Horvath Steve, Geschwind Daniel H   Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap Science (New York, N.Y.), 2018; 359(6376): 693-697.
Gandal Michael J, Leppa Virpi, Won Hyejung, Parikshak Neelroop N, Geschwind Daniel H   The road to precision psychiatry: translating genetics into disease mechanisms Nature neuroscience, 2016; 19(11): 1397-1407.
Parikshak Neelroop N, Swarup Vivek, Belgard T Grant, Irimia Manuel, Ramaswami Gokul, Gandal Michael J, Hartl Christopher, Leppa Virpi, Ubieta Luis de la Torre, Huang Jerry, Lowe Jennifer K, Blencowe Benjamin J, Horvath Steve, Geschwind Daniel H   Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism Nature, 2016; 540(7633): 423-427.
Won Hyejung, de la Torre-Ubieta Luis, Stein Jason L, Parikshak Neelroop N, Huang Jerry, Opland Carli K, Gandal Michael J, Sutton Gavin J, Hormozdiari Farhad, Lu Daning, Lee Changhoon, Eskin Eleazar, Voineagu Irina, Ernst Jason, Geschwind Daniel H   Chromosome conformation elucidates regulatory relationships in developing human brain Nature, 2016; 538(7626): 523-527.
Singh Tarjinder, Walters James T R, Johnstone Mandy, Curtis David, Suvisaari Jaana, Torniainen Minna, Rees Elliott, Iyegbe Conrad, Blackwood Douglas, McIntosh Andrew M, Kirov Georg, Geschwind Daniel, Murray Robin M, Di Forti Marta, Bramon Elvira, Gandal Michael, Hultman Christina M, Sklar Pamela, Sklar Pamela, Sklar Pamela, Palotie Aarno, Sullivan Patrick F, O'Donovan Michael C, Owen Michael J, Barrett Jeffrey C   The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability Nature genetics, 2017; 49(8): 1167-1173.
Gandal Michael J, Geschwind Daniel H   The Genetics-Driven Revival in Neuropsychiatric Drug Development Biological psychiatry, 2016; 79(8): 628-30.
Parikshak Neelroop N, Gandal Michael J, Geschwind Daniel H   Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders Nature reviews. Genetics, 2015; 16(8): 441-58.
Gandal Michael J, Nesbitt Addie May, McCurdy Richard M, Alter Mark D   Measuring the maturity of the fast-spiking interneuron transcriptional program in autism, schizophrenia, and bipolar disorder PloS one, 2012; 7(8): e41215.
Gandal M J, Sisti J, Klook K, Ortinski P I, Leitman V, Liang Y, Thieu T, Anderson R, Pierce R C, Jonak G, Gur R E, Carlson G, Siegel S J   GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction Translational psychiatry, 2012; 2(3): e142.
Gandal Michael J, Edgar J Christopher, Klook Kerstin, Siegel Steven J   Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia Neuropharmacology, 2012; 62(3): 1504-18.
Gandal Michael J, Edgar J Christopher, Ehrlichman Richard S, Mehta Mili, Roberts Timothy P L, Siegel Steven J   Validating γ oscillations and delayed auditory responses as translational biomarkers of autism Biological psychiatry, 2010; 68(12): 1100-6.
Fan Chun Chieh, McGrath John J, Appadurai Vivek, Buil Alfonso, Gandal Michael J, Schork Andrew J, Mortensen Preben Bo, Agerbo Esben, Geschwind Sandy A, Geschwind Daniel, Werge Thomas, Thompson Wesley K, Pedersen Carsten Bøcker   Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia Nature communications, 2018; 9(1): 5296.
Parikshak Neelroop N, Swarup Vivek, Belgard T Grant, Irimia Manuel, Ramaswami Gokul, Gandal Michael J, Hartl Christopher, Leppa Virpi, de la Torre Ubieta Luis, Huang Jerry, Lowe Jennifer K, Blencowe Benjamin J, Horvath Steve, Geschwind Daniel H   Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism Nature, 2018; 560(7718): E30.
Ramaswami Gokul, Won Hyejung, Gandal Michael J, Haney Jillian, Wang Jerry C, Wong Chloe C Y, Sun Wenjie, Prabhakar Shyam, Mill Jonathan, Geschwind Daniel H   Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism Nature communications, 2020; 11(1): 4873.
Schwede Matthew, Nagpal Shailender, Gandal Michael J, Parikshak Neelroop N, Mirnics Karoly, Geschwind Daniel H, Morrow Eric M   Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex Journal of neurodevelopmental disorders, 2018; 10(1): 18.
Haney Jillian R, Parhami Sepideh, Gandal Michael J   Banking on Polygenicity to Disentangle Psychiatric Comorbidity Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018; 3(7): 577-578.
Hernandez Leanna M, Kim Minsoo, Hoftman Gil D, Haney Jillian R, de la Torre-Ubieta Luis, Pasaniuc Bogdan, Gandal Michael J   Transcriptomic Insight Into the Polygenic Mechanisms Underlying Psychiatric Disorders Biological psychiatry, 2020; 11(1): 4873.
Pierre Joseph M, Gandal Michael, Son Maya   Cannabis-induced psychosis associated with high potency "wax dabs" Schizophrenia research, 2016; 172(1-3): 211-2.
Walker Rebecca L, Ramaswami Gokul, Hartl Christopher, Mancuso Nicholas, Gandal Michael J, de la Torre-Ubieta Luis, Pasaniuc Bogdan, Stein Jason L, Geschwind Daniel H   Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell, 2020; 181(3): 745.
Tatard-Leitman Valerie M, Jutzeler Catherine R, Suh Jimmy, Saunders John A, Billingslea Eddie N, Morita Susumu, White Rachel, Featherstone Robert E, Ray Rabindranath, Ortinski Pavel I, Banerjee Anamika, Gandal Michael J, Lin Robert, Alexandrescu Anamaria, Liang Yuling, Gur Raquel E, Borgmann-Winter Karin E, Carlson Gregory C, Hahn Chang-Gyu, Siegel Steven J   Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability Biological psychiatry, 2015; 77(6): 556-68.
Walker Rebecca L, Ramaswami Gokul, Hartl Christopher, Mancuso Nicholas, Gandal Michael J, Torre-Ubieta Luis de la, Pasaniuc Bogdan, Stein Jason L, Geschwind Daniel H   Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell, 2020; 181(2): 484.
Port Russell G, Gandal Michael J, Roberts Timothy P L, Siegel Steven J, Carlson Gregory C   Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology Frontiers in cellular neuroscience, 2014; 8(6): 414.
Forsyth Jennifer K, Nachun Daniel, Gandal Michael J, Geschwind Daniel H, Anderson Ariana E, Coppola Giovanni, Bearden Carrie E   Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders Biological psychiatry, 2020; 87(2): 150-163.
Billingslea Eddie N, Tatard-Leitman Valerie M, Anguiano Jaynie, Jutzeler Catherine R, Suh Jimmy, Saunders John A, Morita Susumu, Featherstone Robert E, Ortinski Pavel I, Gandal Michael J, Lin Robert, Liang Yuling, Gur Raquel E, Carlson Gregory C, Hahn Chang-Gyu, Siegel Steven J   Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014; 39(7): 1603-13.
Dahl Andy, Nguyen Khiem, Cai Na, Gandal Michael J, Flint Jonathan, Zaitlen Noah   A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits American journal of human genetics, 2020; 106(1): 71-91.
Saunders John A, Gandal Michael J, Roberts Timothy P, Siegel Steve J   NMDA antagonist MK801 recreates auditory electrophysiology disruption present in autism and other neurodevelopmental disorders Behavioural brain research, 2012; 234(2): 233-7.
Walker Rebecca L, Ramaswami Gokul, Hartl Christopher, Mancuso Nicholas, Gandal Michael J, de la Torre-Ubieta Luis, Pasaniuc Bogdan, Stein Jason L, Geschwind Daniel H   Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell, 2019; 179(3): 750-771.e22.
Cao Yufei A, Featherstone Robert E, Gandal Michael J, Liang Yuling, Jutzeler Catherine, Saunders John, Tatard-Leitman Valerie, Chen Jingshan, Weinberger Daniel R, Lerman Caryn, Siegel Steven J   Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density Behavioral neuroscience, 2012; 126(2): 332-43.
Lopez Soto Eduardo Javier, Gandal Michael J, Gonatopoulos-Pournatzis Thomas, Heller Elizabeth A, Luo Diou, Zheng Sika   Mechanisms of Neuronal Alternative Splicing and Strategies for Therapeutic Interventions The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019; 39(42): 8193-8199.
Liao Wenlin, Gandal Michael J, Ehrlichman Richard S, Siegel Steven J, Carlson Greg C   MeCP2+/- mouse model of RTT reproduces auditory phenotypes associated with Rett syndrome and replicate select EEG endophenotypes of autism spectrum disorder Neurobiology of disease, 2012; 46(1): 88-92.
Lee Changhoon, Kang Eun Yong, Gandal Michael J, Eskin Eleazar, Geschwind Daniel H   Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage Nature neuroscience, 2019; 22(9): 1521-1532.
Ruzzo Elizabeth K, Pérez-Cano Laura, Jung Jae-Yoon, Wang Lee-Kai, Kashef-Haghighi Dorna, Hartl Chris, Singh Chanpreet, Xu Jin, Hoekstra Jackson N, Leventhal Olivia, Leppä Virpi M, Gandal Michael J, Paskov Kelley, Stockham Nate, Polioudakis Damon, Lowe Jennifer K, Prober David A, Geschwind Daniel H, Wall Dennis P   Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks Cell, 2019; 178(4): 850-866.e26.
Saunders John A, Gandal Michael J, Siegel Steve J   NMDA antagonists recreate signal-to-noise ratio and timing perturbations present in schizophrenia Neurobiology of disease, 2012; 46(1): 93-100.
Sharon Gil, Cruz Nikki Jamie, Kang Dae-Wook, Gandal Michael J, Wang Bo, Kim Young-Mo, Zink Erika M, Casey Cameron P, Taylor Bryn C, Lane Christianne J, Bramer Lisa M, Isern Nancy G, Hoyt David W, Noecker Cecilia, Sweredoski Michael J, Moradian Annie, Borenstein Elhanan, Jansson Janet K, Knight Rob, Metz Thomas O, Lois Carlos, Geschwind Daniel H, Krajmalnik-Brown Rosa, Mazmanian Sarkis K   Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice Cell, 2019; 177(6): 1600-1618.e17.
Mehta Mili V, Gandal Michael J, Siegel Steven J   mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism PloS one, 2011; 6(10): e26077.
Carlson Gregory C, Talbot Konrad, Halene Tobias B, Gandal Michael J, Kazi Hala A, Schlosser Laura, Phung Quan H, Gur Raquel E, Arnold Steven E, Siegel Steven J   Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(43): E962-70.
Kimura Ryo, Swarup Vivek, Tomiwa Kiyotaka, Gandal Michael J, Parikshak Neelroop N, Funabiki Yasuko, Nakata Masatoshi, Awaya Tomonari, Kato Takeo, Iida Kei, Okazaki Shin, Matsushima Kanae, Kato Toshihiro, Murai Toshiya, Heike Toshio, Geschwind Daniel H, Hagiwara Masatoshi   Integrative network analysis reveals biological pathways associated with Williams syndrome Journal of child psychology and psychiatry, and allied disciplines, 2019; 60(5): 585-598.
Amann Laura C, Gandal Michael J, Halene Tobias B, Ehrlichman Richard S, White Samantha L, McCarren Hilary S, Siegel Steven J   Mouse behavioral endophenotypes for schizophrenia Brain research bulletin, 2010; 83(3-4): 147-61.
Gandal Michael J, Haney Jillian R, Parikshak Neelroop N, Leppa Virpi, Ramaswami Gokul, Hartl Chris, Schork Andrew J, Appadurai Vivek, Buil Alfonso, Werge Thomas M, Liu Chunyu, White Kevin P, White Kevin P, Geschwind Daniel H   Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap Focus (American Psychiatric Publishing), 2019; 17(1): 66-72.
Amann Laura C, Gandal Michael J, Lin Robert, Liang Yuling, Siegel Steven J   In vitro-in vivo correlations of scalable PLGA-risperidone implants for the treatment of schizophrenia Pharmaceutical research, 2010; 27(8): 1730-7.
Demontis Ditte, Walters Raymond K, Martin Joanna, Mattheisen Manuel, Als Thomas D, Agerbo Esben, Baldursson Gísli, Belliveau Rich, Bybjerg-Grauholm Jonas, Bækvad-Hansen Marie, Cerrato Felecia, Chambert Kimberly, Churchhouse Claire, Dumont Ashley, Eriksson Nicholas, Gandal Michael, Goldstein Jacqueline I, Grasby Katrina L, Grove Jakob, Gudmundsson Olafur O, Hansen Christine S, Hauberg Mads Engel, Hollegaard Mads V, Howrigan Daniel P, Huang Hailiang, Maller Julian B, Martin Alicia R, Martin Nicholas G, Moran Jennifer, Pallesen Jonatan, Palmer Duncan S, Pedersen Carsten Bøcker, Pedersen Marianne Giørtz, Poterba Timothy, Poulsen Jesper Buchhave, Ripke Stephan, Robinson Elise B, Satterstrom F Kyle, Stefansson Hreinn, Stevens Christine, Turley Patrick, Walters G Bragi, Won Hyejung, Wright Margaret J, Wright Margaret J, Wright Margaret J, Wright Margaret J, Andreassen Ole A, Asherson Philip, Burton Christie L, Boomsma Dorret I, Cormand Bru, Dalsgaard Søren, Franke Barbara, Gelernter Joel, Geschwind Daniel, Hakonarson Hakon, Haavik Jan, Kranzler Henry R, Kuntsi Jonna, Langley Kate, Lesch Klaus-Peter, Middeldorp Christel, Reif Andreas, Rohde Luis Augusto, Roussos Panos, Schachar Russell, Sklar Pamela, Sonuga-Barke Edmund J S, Sullivan Patrick F, Thapar Anita, Tung Joyce Y, Waldman Irwin D, Medland Sarah E, Stefansson Kari, Nordentoft Merete, Hougaard David M, Werge Thomas, Mors Ole, Mortensen Preben Bo, Daly Mark J, Faraone Stephen V, Børglum Anders D, Neale Benjamin M   Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder Nature genetics, 2019; 51(1): 63-75.
Lazarewicz Maciej T, Ehrlichman Richard S, Maxwell Christina R, Gandal Michael J, Finkel Leif H, Siegel Steven J   Ketamine modulates theta and gamma oscillations Journal of cognitive neuroscience, 2010; 22(7): 1452-64.
Wang Daifeng, Liu Shuang, Warrell Jonathan, Won Hyejung, Shi Xu, Navarro Fabio C P, Clarke Declan, Gu Mengting, Emani Prashant, Yang Yucheng T, Xu Min, Gandal Michael J, Lou Shaoke, Zhang Jing, Park Jonathan J, Yan Chengfei, Rhie Suhn Kyong, Manakongtreecheep Kasidet, Zhou Holly, Nathan Aparna, Peters Mette, Mattei Eugenio, Fitzgerald Dominic, Brunetti Tonya, Moore Jill, Jiang Yan, Girdhar Kiran, Hoffman Gabriel E, Kalayci Selim, Gümüş Zeynep H, Crawford Gregory E, Crawford Gregory E, Roussos Panos, Akbarian Schahram, Jaffe Andrew E, White Kevin P, Weng Zhiping, Sestan Nenad, Geschwind Daniel H, Knowles James A, Gerstein Mark B   Comprehensive functional genomic resource and integrative model for the human brain Science (New York, N.Y.), 2018; 362(6420): 63-75.
Karai Laszlo, Brown Dorothy C, Mannes Andrew J, Connelly Stephen T, Brown Jacob, Gandal Michael, Wellisch Ofer M, Neubert John K, Olah Zoltan, Iadarola Michael J   Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control The Journal of clinical investigation, 2004; 113(9): 1344-52.
Gandal Michael J, Zhang Pan, Hadjimichael Evi, Walker Rebecca L, Chen Chao, Liu Shuang, Won Hyejung, van Bakel Harm, Varghese Merina, Wang Yongjun, Shieh Annie W, Haney Jillian, Parhami Sepideh, Belmont Judson, Kim Minsoo, Moran Losada Patricia, Khan Zenab, Mleczko Justyna, Xia Yan, Dai Rujia, Wang Daifeng, Yang Yucheng T, Xu Min, Fish Kenneth, Hof Patrick R, Warrell Jonathan, Fitzgerald Dominic, White Kevin, Jaffe Andrew E, Jaffe Andrew E, Peters Mette A, Gerstein Mark, Liu Chunyu, Iakoucheva Lilia M, Pinto Dalila, Geschwind Daniel H   Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder Science (New York, N.Y.), 2018; 362(6420): 63-75.