Feldman, Jack

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Titles

Distinguished Professor, Neurobiology

Member, Brain Research Institute

Molecular, Cellular & Integrative Physiology GPB Home Area

Neuroscience GPB Home Area

Contact Information

Email
feldman@g.ucla.edu
Phone
Lab Number: (310) 825-1586
Office Phone Number: 310-825-0954
Address

Work Address:

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Publications

A selected list of publications:

Huckstepp Robert TR, Henderson Lauren E, Cardoza Kathryn P, Feldman Jack L   Interactions between respiratory oscillators in adult rats eLife, 2016; 5: .
Yackle Kevin, Schwarz Lindsay A, Kam Kaiwen, Sorokin Jordan M, Huguenard John R, Feldman Jack L, Luo Liqun, Krasnow Mark A   Breathing control center neurons that promote arousal in mice Science (New York, N.Y.), 2017; 355(6332): 1411-1415.
Cui Yan, Kam Kaiwen, Sherman David, Janczewski Wiktor A, Zheng Yu, Feldman Jack L   Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo Neuron, 2016; 91(3): 602-14.
Li Peng, Janczewski Wiktor A, Yackle Kevin, Kam Kaiwen, Pagliardini Silvia, Krasnow Mark A, Feldman Jack L   The peptidergic control circuit for sighing Nature, 2016; 530(7590): 293-7.
Sherman David, Worrell Jason W, Cui Yan, Feldman Jack L   Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern Nature neuroscience, 2015; 18(3): 408-14.
Feldman Jack L, Kam Kaiwen   Facing the challenge of mammalian neural microcircuits: taking a few breaths may help The Journal of physiology, 2015; 593(1): 3-23.
Dick T E, Dutschmann M, Feldman J L, Fong A Y, Hülsmann S, Morris K M, Ramirez J M, Smith J C, Smith J C   Facts and challenges in respiratory neurobiology Respiratory physiology & neurobiology, 2015; 54(19): .
Huckstepp Robert T R, Cardoza Kathryn P, Henderson Lauren E, Feldman Jack L   Role of parafacial nuclei in control of breathing in adult rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(3): 1052-67.
Feldman Jack L, Kam Kaiwen   Facing the challenge of mammalian neural microcircuits: Taking a few breaths may help The Journal of physiology, 2014; 35(3): .
Kam Kaiwen, Worrell Jason W, Janczewski Wiktor A, Cui Yan, Feldman Jack L   Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(22): 9235-45.
Janczewski Wiktor A, Tashima Alexis, Hsu Paul, Cui Yan, Feldman Jack L   Role of inhibition in respiratory pattern generation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(13): 5454-65.
Kam Kaiwen, Worrell Jason W, Ventalon Cathie, Emiliani Valentina, Feldman Jack L   Emergence of population bursts from simultaneous activation of small subsets of preBötzinger complex inspiratory neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(8): 3332-8.
Shao Xuesi M, Xu Bin, Liang Jing, Xie Xinmin Simon, Zhu Yifang, Feldman Jack L   Nicotine Delivery to Rats via Lung Alveolar Region-Targeted Aerosol Technology Produces Blood Pharmacokinetics Resembling Human Smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012; .
Babiec Walter E, Faull Kym F, Feldman Jack L   Cyclothiazide-induced persistent increase in respiratory-related activity in vitro The Journal of physiology, 2012; 590(Pt 19): 4897-915.
Feldman Jack L, Del Negro Christopher A, Gray Paul A   Understanding the Rhythm of Breathing: So Near, Yet So Far Annual review of physiology, 2012; .
Tan Wenbin, Sherman David, Turesson Jenny, Shao Xuesi M, Janczewski Wiktor A, Feldman Jack L   Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat J. Comp. Neurol, 2012; 520(3): 606-19.
Pagliardini Silvia, Janczewski Wiktor A, Tan Wenbin, Dickson Clayton T, Deisseroth Karl, Feldman Jack L   Active expiration induced by excitation of ventral medulla in adult anesthetized rats J. Neurosci, 2011; 31(8): 2895-905.
Feldman Jack L   Chapter 14--looking forward to breathing Prog. Brain. Res, 2011; 188(8): 213-8.
Saywell Shane A, Babiec Walter E, Neverova Natalia V, Feldman Jack L   Protein kinase G-dependent mechanisms modulate hypoglossal motoneuronal excitability and long-term facilitation J. Physiol, 2010; 588(Pt 22): 4431-9.
Schwab David J, Bruinsma Robijn F, Feldman Jack L, Levine Alex J   Rhythmogenic neuronal networks, emergent leaders, and k-cores Phys. Rev. E, 2010; 82(5 Pt 1): 051911.
Tan Wenbin, Pagliardini Silvia, Yang Paul, Janczewski Wiktor A, Feldman Jack L   Projections of preBötzinger complex neurons in adult rats J. Comp. Neurol, 2010; 518(10): 1862-78.
Morgado-Valle Consuelo, Baca Serapio M, Feldman Jack L   Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse J. Neurosci, 2010; 30(10): 3634-9.
Del Negro Christopher A, Hayes John A, Pace Ryland W, Brush Benjamin R, Teruyama Ryoichi, Feldman Jack L   Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals Prog. Brain. Res, 2010; 187(10): 111-36.
Feldman JL, Kam KK, Janczewski WA   Practice makes perfect, even for breathing Nature Neuroscience, 2009; 12(8): 961-3.
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Shao Xuesi M, Feldman Jack L   Central cholinergic regulation of respiration: nicotinic receptors Acta pharmacologica Sinica, 2009; 30(6): 761-70.
Del Negro CA, KK, Hayes JA, Feldman JL   Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro J. Physiol, 2009; 587(Pt 6): 1217-31.
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Morgado-Valle Consuelo, Beltran-Parrazal Luis, DiFranco Marino, Vergara Julio L, Feldman Jack L   Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons The Journal of physiology, 2008; 586(Pt 18): 4531-40.
McKay LC, Feldman JL   Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness American Journal of Respiratory and Critical Care Medicine, 2008; 178(1): 89-95.
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Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL   Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm, J Neurosci, 2008; 28(2): 519-28.
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Feldman, JL, McCrimmon DR   Neural Control of Breathing, Fundamental Neuroscience, 3rd Edition, 2008; .
Tan W, Janczewski WA, Yang Pl, Shao XM, Callaway EM, Feldman JL   Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat Nature Neuroscience, 2008; 11(5): 538-40.
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Shao Xuesi M, Tan Wenbin, Xiu Joanne, Puskar Nyssa, Fonck Carlos, Lester Henry A, Feldman Jack L   Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(2): 519-28.
Pace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A   Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice The Journal of physiology, 2007; 582(Pt 1): 113-25.
Morgado-Valle C, Feldman JL   NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors The Journal of physiology, 2007; 582(Pt 1): 359-68.
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Shao XM, Feldman JL.   Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC, J Neurosci Methods, 2007; 160(2): 256-63.
Neverova NV, Saywell SA, Nashold LJ, Mitchell GS, Feldman JL.   Episodic stimulation of alpha 1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability, J Neurosci, 2007; 27(16): 4435-42.
Pace RW, Mackay DD, Feldman JL, Del Negro CA   Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice, J Physiol, 2007; 582(Pt 1): 113-25.
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Shao XM, Feldman JL.   Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials, J Neurosci Methods, 2007; 159(1): 108-15.
Morgado-Valle C, Feldman JL   NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors, J Physiol, 2007; 582(Pt 1): 359-68.
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Pace RW, Mackay DD, Feldman JL, Del Negro CA.   Role of persistent sodium current in mouse preBotzinger Complex neurons and respiratory rhythm generation, J Physiol, 2007; 580(Pt 2): 485-96.
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Neverova Natalia V, Saywell Shane A, Nashold Lisa J, Mitchell Gordon S, Feldman Jack L   Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(16): 4435-42.
Pace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A   Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation The Journal of physiology, 2007; 580(Pt. 2): 485-96.
Shao Xuesi M, Feldman Jack L   Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC Journal of neuroscience methods, 2007; 160(2): 256-63.
Shao Xuesi M, Feldman Jack L   Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials Journal of neuroscience methods, 2007; 159(1): 108-15.
Feldman Jack L, Janczewski Wiktor A   The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal" Journal of applied physiology (Bethesda, Md. : 1985), 2006; 101(2): 689.
Janczewski Wiktor A, Feldman Jack L   Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats" Journal of neurophysiology, 2006; 96(1): 1-2.
Janczewski WA, Feldman JL   Distinct rhythm generators for inspiration and expiration in the juvenile rat J. Physiol, 2006; 570: 407-420.
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Janczewski WA, Feldman JL.   Distinct rhythm generators for inspiration and expiration in the juvenile rat, J Physiol, 2006; 570(Pt 2): 407-20.
Feldman JL, Del Negro CA   Looking for inspiration: new perspectives on respiratory rhythm, Nature Reviews Neuroscience, 2006; 7(3): 232-42.
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Janczewski WA, Feldman JL.   Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiratory-related rhythmic activity in the rostral medulla of newborn rats", J Neurophysiol, 2006; 96(1): 1-2.
Feldman JL, Janczewski WA.   Point: Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBotC is the primary site of respiratroy rhythm generation in the mammal, J Appl Physiol, 2006; 100(6): 2096-7.
Feldman JL, Janczewski WA.   The Last Word: Point: Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/ pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal", J Appl Physiol, 2006; 101(2): 689.
Feldman Jack L, Janczewski Wiktor A   Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal Journal of applied physiology (Bethesda, Md. : 1985), 2006; 100(6): 2096-7; discussion 2097-8, 2103-8.
Feldman Jack L, Del Negro Christopher A   Looking for inspiration: new perspectives on respiratory rhythm Nature reviews. Neuroscience, 2006; 7(3): 232-42.
Janczewski Wiktor A, Feldman Jack L   Distinct rhythm generators for inspiration and expiration in the juvenile rat The Journal of physiology, 2006; 570(Pt 2): 407-20.
McKay LC, Janczewski WA, Feldman JL   Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons Nature Neuroscience, 2005; 8(9): 1142-4.
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Feldman Jack L, Neverova Natalia V, Saywell Shane A   Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades Respiratory physiology & neurobiology, 2005; 147(2-3): 131-43.
Shao XM, Feldman JL.   Cholinergic neurotransmission in the preBotzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm, Neuroscience, 2005; 130(4): 1069-81.
Feldman JL, Neverova NV, Saywell SA.   Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades, Respir Physiol Neurobiol, 2005; 147(2-3): 131-43.
McKay LC, Janczewski WA, Feldman JL   Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons Nature Neuroscience, 2005; 8(9): 1142-1144.
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Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL.   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation, J Neurosci, 2005; 25(2): 446-53.
Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation J. Neurosci, 2005; 25(2): 446-53.
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Del Negro Christopher A, Morgado-Valle Consuelo, Hayes John A, Mackay Devin D, Pace Ryland W, Crowder Erin A, Feldman Jack L   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(2): 446-53.
Feldman Jack L, Janczewski Wiktor A   Slip of the tongue American journal of respiratory and critical care medicine, 2004; 170(6): 581-2.
Feldman JL, Janczewski WA.   Slip of the tongue, Am J Respir Crit Care Med, 2004; 170(6): 581-2.
Mellen Nicholas M, Roham Maryam, Feldman Jack L   Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms The Journal of physiology, 2004; 556(Pt 3): 859-74.
McKay Leanne C, Janczewski Wiktor A, Feldman Jack L   Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats The Journal of physiology, 2004; 557(Pt 1): 13-8.
Bocchiaro CM, Feldman JL   Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons PNAS, 2004; 101(12): 4292-5.
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Morgado-Valle Consuelo, Feldman Jack L   Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro The Journal of physiology, 2004; 555(Pt 3): 783-92.
Bocchiaro Christopher M, Feldman Jack L   Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(12): 4292-5.
Saywell, SA Feldman, JL   Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA The Journal of physiology. , 2004; 554(Pt 3): 879-89.
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Parkis, MA Feldman, JL Robinson, DM Funk, GD   Oscillations in endogenous inputs to neurons affect excitability and signal processing The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(22): 8152-8.
Feldman JL, Mitchell GS, Nattie EE   Breathing: rhythmicity, plasticity, chemosensitivity Annual Review of Neuroscience, 2003; 26: 239-66.
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Shao XM, Ge Q, Feldman JL   Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat, J Physiol, 2003; 545(Pt 2): 543-53.
Mellen NM, Janczewski WA, Bocchiaro CM, Feldman, JL   Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation Neuron, 2003; 37(5): 821-6.
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Bocchiaro CM, Saywell SA, Feldman JL   Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons J. Neurosci, 2003; 23(4): 1099-103.
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Janczewski WA, Onimaru H, Homma I, Feldman JL   Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat J. Physiol, 2002; 545(Pt 3): 1017-26.
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Chamberlin, NL Bocchiaro, CM Greene, RW Feldman, JL   Nicotinic excitation of rat hypoglossal motoneurons Neuroscience. , 2002; 115(3): 861-70.
Alheid, GF Gray, PA Jiang, MC Feldman, JL McCrimmon, DR   Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat Journal of neurocytology. , 2002; 31(8-9): 693-717.
Shao XM, Feldman JL   Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern, J Neurophysiol, 2002; 88(4): 1851-8.
Del Negro CA, Morgado-Valle C, Feldman JL   Respiratory rhythm: an emergent network property? Neuron, 2002; 34(5): 821-30.
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Mellen Nicholas M, Milsom William K, Feldman Jack L   Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation American journal of physiology. Regulatory, integrative and comparative physiology, 2002; 282(2): R484-91.
Mellen, NM Milsom, WK Feldman, JL   Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation American journal of physiology. Regulatory, integrative and comparative physiology. , 2002; 282(2): R484-91.
Mellen, NM Feldman, JL   Phasic vagal sensory feedback transforms respiratory neuron activity in vitro The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(18): 7363-71.
Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL   Normal breathing requires preBotzinger Complex neurokinin-1 receptor expressing neurons, Nature Neuroscience, 2001; 4(9): 927-930.
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Lai J, Shao XM, Pan RW, Dy E, Huang CH, Feldman JL   RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzinger complex, Am J Physiol Lung Cell Mol Physiol, 2001; 281(6): L1420-4.
Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL   Synaptic control of motoneuronal excitability Physiological Reviews , 2000; 80(2): 767-852.
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Gray PA, Rekling JC, Bocchiaro CM, Feldman JL   Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex Science, 1999; 286: 1566-1568.
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Rekling JC, Feldman JL   PreBötzinger Complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation Annual Review of Physiology, 1998; 60: 385-405.
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Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL   PreBötzinger Complex: A brain region that may generate respiratory rhythm in mammals, Science, 1991; 254: 726-729.
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