Feldman, Jack

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Titles

Distinguished Professor, Neurobiology

Contact Information

Email
feldman@g.ucla.edu
Phone
Lab Number: (310) 825-1586
Office Phone Number: 310-825-0954
Address

Work Address:

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Biography

Professor Feldman revolutionized our understanding the neural control of breathing. He is renowned for: i) his groundbreaking discovery (and naming) of the preBötzinger Complex, demonstrating its essential role in generating respiratory rhythm in fetal, neonatal and adult mammals. This discovery is the foundation for the current paradigm for generation of breathing pattern; the role of the preBötC is presented in textbooks and routinely taught to graduate and medical students. Feldman’s breakthrough was made possible by his labs development of a novel neonatal rodent in vitro slice preparation, still unique for studying meaningful behavior in a slice. (In the course of this work, Feldman’s laboratory developed an intact neonatal spinal cord preparation for study of locomotion that still continues as to be the basis for major advances in understanding locomotion). His laboratory identified the first protein marker for preBötC neurons, invaluable for novel experimentation, making breathing accessible to molecular manipulations and exploitation of engineered mice. Feldman rigorously tested in vitro discoveries with sophisticated and novel in vivo experiments. ii) discovery (and naming) of the retrotrapezoid nucleus (RTN) and the ultimately validated hypothesis of its essential role in central chemoreception. iii) The two oscillator hypothesis (now well accepted) of the preBötC as driving inspiratory motor output and the RTN/parafacial respiratory group as a second oscillator driving expiratory motor output. Feldman and colleagues have delineated a compact circuit between the preBötC and RTN that rhythmically generates sighs essential for maintenance of lung function and identified ascending preBötC neurons that modulate emotional state. Most recently, Feldman and colleagues have proposed a novel mechanism underlying generation of breathing rhythm. The considerable influence of Feldman’s ideas is evident in numerous highly cited review, textbook chapters, online lectures and podcasts that also communicate the state of the art to neuroscientists and physiologists as well as to those outside academia. Among his awards is the prestigious Hodgkin, Huxley, Katz Prize of THE PHYSIOLOGICAL SOCIETY. 

Publications

A selected list of publications:

Huckstepp Robert TR, Henderson Lauren E, Cardoza Kathryn P, Feldman Jack L   Interactions between respiratory oscillators in adult rats eLife, 2016; 5: .
Weng Helen Y, Feldman Jack L, Leggio Lorenzo, Napadow Vitaly, Park Jeanie, Price Cynthia J   Interventions and Manipulations of Interoception Trends in neurosciences, 2021; 44(1): 52-62.
Yang Cindy F, Kim Euiseok J, Callaway Edward M, Feldman Jack L   Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons Frontiers in neuroanatomy, 2020; 14(1): 58.
Simonson Tatum S, Baker Tracy L, Banzett Robert B, Bishop Tammie, Dempsey Jerome A, Feldman Jack L, Guyenet Patrice G, Hodson Emma J, Mitchell Gordon S, Moya Esteban A, Nokes Brandon T, Orr Jeremy E, Owens Robert L, Poulin Marc, Rawling Jean M, Schmickl Christopher N, Watters Jyoti J, Younes Magdy, Malhotra Atul   Silent hypoxaemia in COVID-19 patients The Journal of physiology, 2020; 44(1): 52-62.
Ashhad Sufyan, Feldman Jack L   Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation Neuron, 2020; 106(3): 482-497.e4.
Sun Xiaolu, Thörn Pérez Carolina, Halemani D Nagaraj, Shao Xuesi M, Greenwood Morgan, Heath Sarah, Feldman Jack L, Kam Kaiwen   Opioids modulate an emergent rhythmogenic process to depress breathing eLife, 2019; 8(3): 482-497.e4.
Shao Xuesi M, Liu Siyu, Lee Eon S, Fung David, Pei Hua, Liang Jing, Mudgway Ross, Zhang Jingxi, Feldman Jack L, Zhu Yifang, Louie Stan, Xie Xinmin S   Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers Journal of applied physiology (Bethesda, Md. : 1985), 2018; 125(5): 1555-1562.
Huckstepp Robert T R, Cardoza Kathryn P, Henderson Lauren E, Feldman Jack L   Distinct parafacial regions in control of breathing in adult rats PloS one, 2018; 13(8): e0201485.
Del Negro Christopher A, Funk Gregory D, Feldman Jack L   Breathing matters Nature reviews. Neuroscience, 2018; 19(6): 351-367.
Yang Cindy F, Feldman Jack L   Efferent projections of excitatory and inhibitory preBötzinger Complex neurons The Journal of comparative neurology, 2018; 526(8): 1389-1402.
Shao Xuesi M, López-Valdés Héctor E, Liang Jing, Feldman Jack L   Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats Scientific reports, 2017; 7(1): 16974.
Yackle Kevin, Schwarz Lindsay A, Kam Kaiwen, Sorokin Jordan M, Huguenard John R, Feldman Jack L, Luo Liqun, Krasnow Mark A   Breathing control center neurons that promote arousal in mice Science (New York, N.Y.), 2017; 355(6332): 1411-1415.
Cui Yan, Kam Kaiwen, Sherman David, Janczewski Wiktor A, Zheng Yu, Feldman Jack L   Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo Neuron, 2016; 91(3): 602-14.
Li Peng, Janczewski Wiktor A, Yackle Kevin, Kam Kaiwen, Pagliardini Silvia, Krasnow Mark A, Feldman Jack L   The peptidergic control circuit for sighing Nature, 2016; 530(7590): 293-7.
Sherman David, Worrell Jason W, Cui Yan, Feldman Jack L   Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern Nature neuroscience, 2015; 18(3): 408-14.
Feldman Jack L, Kam Kaiwen   Facing the challenge of mammalian neural microcircuits: taking a few breaths may help The Journal of physiology, 2015; 593(1): 3-23.
Dick T E, Dutschmann M, Feldman J L, Fong A Y, Hülsmann S, Morris K M, Ramirez J M, Smith J C, Smith J C   Facts and challenges in respiratory neurobiology Respiratory physiology & neurobiology, 2015; 54(19): .
Huckstepp Robert T R, Cardoza Kathryn P, Henderson Lauren E, Feldman Jack L   Role of parafacial nuclei in control of breathing in adult rats The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015; 35(3): 1052-67.
Feldman Jack L, Kam Kaiwen   Facing the challenge of mammalian neural microcircuits: Taking a few breaths may help The Journal of physiology, 2014; 35(3): .
Kam Kaiwen, Worrell Jason W, Janczewski Wiktor A, Cui Yan, Feldman Jack L   Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(22): 9235-45.
Janczewski Wiktor A, Tashima Alexis, Hsu Paul, Cui Yan, Feldman Jack L   Role of inhibition in respiratory pattern generation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(13): 5454-65.
Kam Kaiwen, Worrell Jason W, Ventalon Cathie, Emiliani Valentina, Feldman Jack L   Emergence of population bursts from simultaneous activation of small subsets of preBötzinger complex inspiratory neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(8): 3332-8.
Shao Xuesi M, Xu Bin, Liang Jing, Xie Xinmin Simon, Zhu Yifang, Feldman Jack L   Nicotine Delivery to Rats via Lung Alveolar Region-Targeted Aerosol Technology Produces Blood Pharmacokinetics Resembling Human Smoking Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012; .
Babiec Walter E, Faull Kym F, Feldman Jack L   Cyclothiazide-induced persistent increase in respiratory-related activity in vitro The Journal of physiology, 2012; 590(Pt 19): 4897-915.
Feldman Jack L, Del Negro Christopher A, Gray Paul A   Understanding the Rhythm of Breathing: So Near, Yet So Far Annual review of physiology, 2012; .
Tan Wenbin, Sherman David, Turesson Jenny, Shao Xuesi M, Janczewski Wiktor A, Feldman Jack L   Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat J. Comp. Neurol, 2012; 520(3): 606-19.
Pagliardini Silvia, Janczewski Wiktor A, Tan Wenbin, Dickson Clayton T, Deisseroth Karl, Feldman Jack L   Active expiration induced by excitation of ventral medulla in adult anesthetized rats J. Neurosci, 2011; 31(8): 2895-905.
Feldman Jack L   Chapter 14--looking forward to breathing Prog. Brain. Res, 2011; 188(8): 213-8.
Saywell Shane A, Babiec Walter E, Neverova Natalia V, Feldman Jack L   Protein kinase G-dependent mechanisms modulate hypoglossal motoneuronal excitability and long-term facilitation J. Physiol, 2010; 588(Pt 22): 4431-9.
Schwab David J, Bruinsma Robijn F, Feldman Jack L, Levine Alex J   Rhythmogenic neuronal networks, emergent leaders, and k-cores Phys. Rev. E, 2010; 82(5 Pt 1): 051911.
Tan Wenbin, Pagliardini Silvia, Yang Paul, Janczewski Wiktor A, Feldman Jack L   Projections of preBötzinger complex neurons in adult rats J. Comp. Neurol, 2010; 518(10): 1862-78.
Morgado-Valle Consuelo, Baca Serapio M, Feldman Jack L   Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse J. Neurosci, 2010; 30(10): 3634-9.
Del Negro Christopher A, Hayes John A, Pace Ryland W, Brush Benjamin R, Teruyama Ryoichi, Feldman Jack L   Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals Prog. Brain. Res, 2010; 187(10): 111-36.
Feldman JL, Kam KK, Janczewski WA   Practice makes perfect, even for breathing Nature Neuroscience, 2009; 12(8): 961-3.
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Shao Xuesi M, Feldman Jack L   Central cholinergic regulation of respiration: nicotinic receptors Acta pharmacologica Sinica, 2009; 30(6): 761-70.
Morgado-Valle Consuelo, Beltran-Parrazal Luis, DiFranco Marino, Vergara Julio L, Feldman Jack L   Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons The Journal of physiology, 2008; 586(Pt 18): 4531-40.
McKay LC, Feldman JL   Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness American Journal of Respiratory and Critical Care Medicine, 2008; 178(1): 89-95.
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Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL   Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm, J Neurosci, 2008; 28(2): 519-28.
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Feldman, JL, McCrimmon DR   Neural Control of Breathing, Fundamental Neuroscience, 3rd Edition, 2008; .
Tan W, Janczewski WA, Yang Pl, Shao XM, Callaway EM, Feldman JL   Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat Nature Neuroscience, 2008; 11(5): 538-40.
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Shao Xuesi M, Tan Wenbin, Xiu Joanne, Puskar Nyssa, Fonck Carlos, Lester Henry A, Feldman Jack L   Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(2): 519-28.
Pace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A   Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice The Journal of physiology, 2007; 582(Pt 1): 113-25.
Morgado-Valle C, Feldman JL   NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors The Journal of physiology, 2007; 582(Pt 1): 359-68.
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Shao XM, Feldman JL.   Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC, J Neurosci Methods, 2007; 160(2): 256-63.
Neverova NV, Saywell SA, Nashold LJ, Mitchell GS, Feldman JL.   Episodic stimulation of alpha 1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability, J Neurosci, 2007; 27(16): 4435-42.
Pace RW, Mackay DD, Feldman JL, Del Negro CA   Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice, J Physiol, 2007; 582(Pt 1): 113-25.
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Shao XM, Feldman JL.   Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials, J Neurosci Methods, 2007; 159(1): 108-15.
Morgado-Valle C, Feldman JL   NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors, J Physiol, 2007; 582(Pt 1): 359-68.
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Pace RW, Mackay DD, Feldman JL, Del Negro CA.   Role of persistent sodium current in mouse preBotzinger Complex neurons and respiratory rhythm generation, J Physiol, 2007; 580(Pt 2): 485-96.
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Neverova Natalia V, Saywell Shane A, Nashold Lisa J, Mitchell Gordon S, Feldman Jack L   Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(16): 4435-42.
Pace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A   Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation The Journal of physiology, 2007; 580(Pt. 2): 485-96.
Shao Xuesi M, Feldman Jack L   Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC Journal of neuroscience methods, 2007; 160(2): 256-63.
Shao Xuesi M, Feldman Jack L   Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials Journal of neuroscience methods, 2007; 159(1): 108-15.
Janczewski WA, Feldman JL   Distinct rhythm generators for inspiration and expiration in the juvenile rat J. Physiol, 2006; 570: 407-420.
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Janczewski WA, Feldman JL.   Distinct rhythm generators for inspiration and expiration in the juvenile rat, J Physiol, 2006; 570(Pt 2): 407-20.
Feldman JL, Del Negro CA   Looking for inspiration: new perspectives on respiratory rhythm, Nature Reviews Neuroscience, 2006; 7(3): 232-42.
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Janczewski WA, Feldman JL.   Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiratory-related rhythmic activity in the rostral medulla of newborn rats", J Neurophysiol, 2006; 96(1): 1-2.
Feldman JL, Janczewski WA.   Point: Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBotC is the primary site of respiratroy rhythm generation in the mammal, J Appl Physiol, 2006; 100(6): 2096-7.
Feldman JL, Janczewski WA.   The Last Word: Point: Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/ pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal", J Appl Physiol, 2006; 101(2): 689.
Feldman Jack L, Del Negro Christopher A   Looking for inspiration: new perspectives on respiratory rhythm Nature reviews. Neuroscience, 2006; 7(3): 232-42.
Janczewski Wiktor A, Feldman Jack L   Distinct rhythm generators for inspiration and expiration in the juvenile rat The Journal of physiology, 2006; 570(Pt 2): 407-20.
McKay LC, Janczewski WA, Feldman JL   Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons Nature Neuroscience, 2005; 8(9): 1142-4.
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Feldman Jack L, Neverova Natalia V, Saywell Shane A   Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades Respiratory physiology & neurobiology, 2005; 147(2-3): 131-43.
Shao XM, Feldman JL.   Cholinergic neurotransmission in the preBotzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm, Neuroscience, 2005; 130(4): 1069-81.
Feldman JL, Neverova NV, Saywell SA.   Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades, Respir Physiol Neurobiol, 2005; 147(2-3): 131-43.
McKay LC, Janczewski WA, Feldman JL   Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons Nature Neuroscience, 2005; 8(9): 1142-1144.
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Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL.   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation, J Neurosci, 2005; 25(2): 446-53.
Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation J. Neurosci, 2005; 25(2): 446-53.
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Del Negro Christopher A, Morgado-Valle Consuelo, Hayes John A, Mackay Devin D, Pace Ryland W, Crowder Erin A, Feldman Jack L   Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(2): 446-53.
Feldman Jack L, Janczewski Wiktor A   Slip of the tongue American journal of respiratory and critical care medicine, 2004; 170(6): 581-2.
Feldman JL, Janczewski WA.   Slip of the tongue, Am J Respir Crit Care Med, 2004; 170(6): 581-2.
Mellen Nicholas M, Roham Maryam, Feldman Jack L   Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms The Journal of physiology, 2004; 556(Pt 3): 859-74.
McKay Leanne C, Janczewski Wiktor A, Feldman Jack L   Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats The Journal of physiology, 2004; 557(Pt 1): 13-8.
Morgado-Valle Consuelo, Feldman Jack L   Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro The Journal of physiology, 2004; 555(Pt 3): 783-92.
Bocchiaro Christopher M, Feldman Jack L   Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(12): 4292-5.
Parkis, MA Feldman, JL Robinson, DM Funk, GD   Oscillations in endogenous inputs to neurons affect excitability and signal processing The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2003; 23(22): 8152-8.
Feldman JL, Mitchell GS, Nattie EE   Breathing: rhythmicity, plasticity, chemosensitivity Annual Review of Neuroscience, 2003; 26: 239-66.
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Shao XM, Ge Q, Feldman JL   Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat, J Physiol, 2003; 545(Pt 2): 543-53.
Mellen NM, Janczewski WA, Bocchiaro CM, Feldman, JL   Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation Neuron, 2003; 37(5): 821-6.
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Chamberlin, NL Bocchiaro, CM Greene, RW Feldman, JL   Nicotinic excitation of rat hypoglossal motoneurons Neuroscience. , 2002; 115(3): 861-70.
Alheid, GF Gray, PA Jiang, MC Feldman, JL McCrimmon, DR   Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat Journal of neurocytology. , 2002; 31(8-9): 693-717.
Shao XM, Feldman JL   Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern, J Neurophysiol, 2002; 88(4): 1851-8.
Del Negro CA, Morgado-Valle C, Feldman JL   Respiratory rhythm: an emergent network property? Neuron, 2002; 34(5): 821-30.
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Mellen Nicholas M, Milsom William K, Feldman Jack L   Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation American journal of physiology. Regulatory, integrative and comparative physiology, 2002; 282(2): R484-91.
Mellen, NM Milsom, WK Feldman, JL   Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation American journal of physiology. Regulatory, integrative and comparative physiology. , 2002; 282(2): R484-91.
Mellen, NM Feldman, JL   Phasic vagal sensory feedback transforms respiratory neuron activity in vitro The Journal of neuroscience : the official journal of the Society for Neuroscience. , 2001; 21(18): 7363-71.
Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL   Normal breathing requires preBotzinger Complex neurokinin-1 receptor expressing neurons, Nature Neuroscience, 2001; 4(9): 927-930.
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Lai J, Shao XM, Pan RW, Dy E, Huang CH, Feldman JL   RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzinger complex, Am J Physiol Lung Cell Mol Physiol, 2001; 281(6): L1420-4.
Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL   Synaptic control of motoneuronal excitability Physiological Reviews , 2000; 80(2): 767-852.
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Gray PA, Rekling JC, Bocchiaro CM, Feldman JL   Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex Science, 1999; 286: 1566-1568.
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Rekling JC, Feldman JL   PreBötzinger Complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation Annual Review of Physiology, 1998; 60: 385-405.
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Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL   PreBötzinger Complex: A brain region that may generate respiratory rhythm in mammals, Science, 1991; 254: 726-729.
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