Brain Research Institute
The Brain Research Institute occupies the Gonda (Goldschmied) Neuroscience and Genetics Research Center and is devoted to a broad spectrum of research programs investigating the nervous system at all levels. It is also a collegial association of more than
225 faculty, as well as their students and technical staff from 20 different departments on campus, united by their interest in problems of brain function and disease. The Institute promotes collaborations among its members by organizing interactive research programs, core facilities, lectures, conferences, and poster sessions.
Ahmanson Laboratory of Neurobiology
The Ahmanson Laboratory of Neurobiology brings together investigators from eight departments with common interests in cellular neurobiology. Molecular, biophysical, physiological, optical, and anatomical approaches are used in studying ion channels and their structure-function relationships, mechanisms
of excitation-contraction and excitation-secretion coupling, modulation and plasticity in synaptic function, sensory transduction, simple neural circuits and the ultrastructure of biologically important membrane proteins. The Ahmanson Laboratory is home of the NIH-funded Cellular Neurobiology
Alzheimer's Disease Research Center
The Alzheimer Disease Research Center (ADRC), supported by the National Institute on Aging, integrates, coordinates, and supports research on Alzheimer's disease and aging. The ADRC is an umbrella structure coordinating AD-related research activities within the UCLA community and is a core source of support (e.g., resources, patients, tissue, expert consultation for research, clinical and training activities) in the greater Los Angeles region. The ADRC has been
involved in numerous studies of experimental drugs for treatment of Alzheimer's disease.
Brain Mapping Program
The Brain Mapping Program brings together faculty experts in a wide range of imaging techniques with state of the art structural and functional imaging equipment in a newly completed 13,000 square foot center devoted purely to neuroscience research. Available methods include: 3 tesla magnetic resonance imaging (MRI, optimized for functional MRI and capable of MRA and MRS), positron emission tomography (PET), optical intrinsic signal imaging, post-mortem cryomacrotome, digital neuroanatomy as well as the computational techniques for data acquisition, analysis, and visualization. Faculty interests range from the study of normal brain function to exploration of disease states in children, adults, and the elderly.
Center for Study of Opioid Receptors and Drugs of Abuse
This Center consists of a multidisciplinary group of faculty who study molecular, cellular, electrophysiological, neuroanatomical, and behavioral aspects of opioids. The overall goals are to gain insights into the actions of opiates that contribute to addiction, tolerance, and
Clinical Neurophysiology Program
This interdisciplinary program, supported by the National Institutes of Health, centers around a surgical program for epilepsy in which use of diagnostic recording sites within the brain enables localization of seizure loci. Participants from the Departments of Neurology, Surgery, Psychiatry, Radiology, and the Brain Research Institute comprise one of the few groups in the world where such basic studies of human brain function and neuropathology can be carried out.
Crump Institute for Biological Imaging
The Institute brings together the disciplines of physics, chemistry,
biochemistry, molecular and cellular biology, immunology, computational sciences,
biomathematics, and neurovascular and cardiovascular sciences
for the exploration, development, and application of biological imaging. The Institute provides the resources where faculty, students and staff from these many different disciplines can come together to produce new
The expected outcome is a new field of biological imaging, as well as the evolution of a clinical practice based on these principles, in which biochemical and biological examinations of patients are performed to improve clinical care.
CURE: Digestive Diseases Research
Founded in 1974, the Center for Ulcer Research and Education (CURE) studies gastrointestinal physiology and neuronal control of gastrointestinal function. Special areas of research include brain-gut interactions, receptors and signal transduction, membrane pumps and channels, intestinal transporters, whole animal physiology, and transgenic models. Human studies emphasize pathophysiology and treatment of peptic conditions and of functional bowel syndromes.
(Goldschmied) Neuroscience and Genetics Research Building
One of the largest individual gifts in University of California history has led to the construction of this
center for neuroscience research. Completed in 1998, the building's architecture reflects UCLA's commitment to close interactions
among neuroscientists, molecular biologists, and geneticists.
Jules Stein Eye Institute
The Institute is one of the best equipped centers for research and treatment
of eye diseases anywhere in the world. This comprehensive facility is devoted
to the study of vision, the care of patients with eye disease, and education in the broad field of ophthalmology. Outpatient, inpatient, and surgical facilities
Laboratory of Neuroendocrinology
This laboratory is a highly interactive group of faculty laboratories that collaborate in research and training in neuroendocrinology. In weekly meetings
of faculty and students, research ideas are discussed and critiqued. Research interests include hormonal control of neural function and behavior, sexual differentiation of the brain, molecular mechanisms of hormone synthesis and action in brain, and aging of reproductive
Laboratory of NeuroImaging (LONI)
The Laboratory of NeuroImaging (LONI) offers exciting opportunities for
students in the Interdepartmental Ph.D. Program for Neuroscience. LONI acts as
the hub of a national neuroimaging resource which supports over 60 national and
international brain imaging collaborations. These collaborations apply
novel image analysis approaches to investigate brain structure and
function in health and disease. One project is analyzing and mapping
early brain change in Alzheimer's disease. It aims to understand how
early the disease can be detected, and how metabolic (PET), functional (fMRI) and anatomic (MRI) changes link with
molecular and cellular
hallmarks of the disease, such as beta-amyloid and neurofibrillary
tangles. Another project charts brain change in schizophrenia, relating
anatomy and functional change in the disease to genetic and medication
effects. Graduate students at LONI are also working with optical imaging,
cryosection imaging and cytoarchitectural mapping to help understand the
structure and function of the normal and diseased brain. The laboratory also
an optical imaging program that studies neurovascular coupling and other
hemodynamic changes during functional activity in animal models and humans
measured intraoperatively during open craniotomies. Overall, these
studies aim to introduce students to the neurobiological and technical
aspects of brain imaging, helping them apply imaging technology to their
own neuroscience questions.
Laboratory of Neuromuscular Plasticity
This lab conducts a program project, "Neuromuscular Plasticity: Functional Recovery After Spinalization." Its research is subdivided into three projects: plasticity of the neural and muscular systems in response to varying activity levels and growth factors; plasticity of the locomotor system, specifically as
it relates to the spinal cord and the motor control of stepping; and the optimization of techniques to rehabilitate humans following spinal cord injury. The study of neuromuscular plasticity in response to
space flight is also an important component of the lab's research activities.
There are more than 20 libraries on the UCLA campus of which the Louise Darling Biomedical Library is the most pertinent to neuroscience. Located in the Center for Health Sciences, it serves students, staff and faculty in all the health and life science disciplines. It is noted for its extensive digital resources and its periodical, reference, and historical collections that are a comprehensive resource for neuroscience research. For historical references, the
Neuroscience History Archives is a unique resource promoting knowledge and appreciation of the discipline's rich history, and complementing the Biomedical Library's rare books and special collections in neural and behavioral sciences.
MacDonald Medical Research Laboratories
The MacDonald Medical Research Laboratories provide a centralized site for biomedical research in several disciplines including neuroscience. Research is carried out here by scientists from various departments of the School of Medicine and the Howard Hughes Medical Institute.
Mental Retardation Research Center
The Center houses laboratories and core facilities for training in basic and clinical research in brain development and neural function. Its scientific activities are diverse, and include fundamental studies on glial biology, demyelination, neural cell differentiation, molecular neurobiology, neurophysiology, neurogenetics, inherited metabolic diseases, neural repair, drug abuse, and self-injurious behavior. Faculty and students meet regularly at informal gatherings, such as half-day mini-retreats and an annual weekend retreat, to share results and discuss ongoing research. The core facilities provide services to assist faculty and students in research.
Molecular Biology Institute
The Molecular Biology Institute, or MBI, is an interdepartmental organization of molecular biologists designed to promote research and teaching at UCLA in
the area of molecular biology. To achieve this goal, the MBI is organized into two interacting administrative units: The MBI Interdepartmental Ph.D. Program, and the MBI Organized Research Unit (ORU). The Molecular Biology Institute is located in Paul D. Boyer Hall, named for the Institute's founding director, the recipient of the 1997 Nobel Prize in Chemistry.
Neural Repair Program
The Training Program in Neural Repair fosters communication, education, and collaboration among 24 UCLA laboratories in the area of degenerative diseases
of the nervous system. The group meets weekly to discuss basic research and its application to plasticity and repair of the damaged nervous system, and sponsors courses, symposia, and guest speakers.
This institute is devoted to education, research, and patient care in psychiatry, neurology, and related fields. The mission of the institute is to acquire new knowledge about the factors affecting social, psychological, intellectual and neurological health; training professionals in mental health, mental retardation, and diseases of the nervous system within an interdisciplinary setting; and developing and utilizing the most effective techniques for diagnosing and treating these disorders.
Neuroscience History Archives
The Neuroscience History Archives (NHA) promotes the advancement and diffusion of knowledge about the history of neuroscience. Through the identification, collection, and preservation of primary source material of twentieth century American neuroscience, the NHA seeks to create a documentary heritage for future generations that will represent the ideas, actions, and accomplishments of the discipline's antecedent practitioners.
Reed Neurological Research Center
This seven-floor structure houses the Department of Neurology, and
has laboratories for clinical and basic research in neurological diseases.
The RNRC also houses the Division of Brain Mapping, which is committed
to the study of human brain structure and function in health and disease.
Sleep Disorders Clinic
Located in the Reed Neurological Research Center and the Neurology Clinic,
the Sleep Disorders Clinic provides facilities for the diagnosis and treatment of sleep apnea syndromes, narcolepsy, nocturnal myoclonus, and other human sleep disorders. The Sleep Disorders Laboratory utilizes state-of-the-art electrophysiological recording and computing equipment for diagnostic nocturnal polysomnography and analysis of physiological data. Affiliated research programs conducted in the Brain Research Institute are investigating basic mechanisms
of cardiorespiratory control and other autonomic functions during sleep.
Udall Parkinson's Disease Research Center of Excellence
UCLA has established one of eight new Udall Research Centers funded by the National Institute of Neurological Diseases and Stroke in its effort to defeat Parkinson's Disease. The UCLA Udall Center undertakes basic and clinical research on Parkinson's Disease, including development of novel engineering techniques for treatment of this disease.